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  • 产品名称：Anti-CISH antibody (1-257) (STJ28208)

  • 产品型号：STJ28208
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CISH antibody (1-257) (STJ28208)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CISH (1-257) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CISH
Gene ID: 1154
Uniprot ID: CISH_HUMAN
Immunogen Region: 1-257
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-257 of human CISH (NP_659508.1).
Immunogen Sequence: MVLCVQGPRPLLAVERTGQR PLWAPSLELPKPVMQPLPAG AFLEEVAEGTPAQTESEPKV LDPEEDLLCIAKTFSYLRES GWYWGSITASEARQHLQKMP EGTFLVRDSTHPSYLFTLSV KTTRGPTNVRIEYADSSFRL DSNCLSRPRILAFPDVVSLV QHYVASCTADTRSDSPDPAP TPALPMPKEDAPSDPALPAP PPATAVHLKLVQPFVRRSSA RSLQHLCRLVINRLVADVD
Tissue Specificity Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct.
Post Translational Modifications Association with EPOR may target the protein for proteolysis by the ubiquitin-dependent proteasome pathway. CIS is mainly monubiquitinated (37 kDa form) but may also exist in a polyubiquitinated form (45 kDa).
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Name Cytokine-Inducible Sh2-Containing Protein
Cis
Cis-1
Protein G18
Suppressor Of Cytokine Signaling
Socs
Database Links Reactome: R-HSA-1266695
Reactome: R-HSA-8951664
Reactome: R-HSA-982772
Alternative Antibody Names Anti-Cytokine-Inducible Sh2-Containing Protein antibody
Anti-Cis antibody
Anti-Cis-1 antibody
Anti-Protein G18 antibody
Anti-Suppressor Of Cytokine Signaling antibody
Anti-Socs antibody
Anti-CISH antibody
Anti-G18 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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