产品详情
简单介绍:
Anti-CITED2 antibody (1-100) (STJ11105425)
详情介绍:
Host: | Rabbit |
Applications: | WB |
Reactivity: | Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Cbp/P300-Interacting Transactivator 2 (1-100) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% thimerosal, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:1000-1:5000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | CITED2 |
Gene ID: | 10370 |
Uniprot ID: | CITE2_HUMAN |
Immunogen Region: | 1-100 |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CITED2 (NP_001161860.1). |
Immunogen Sequence: | MADHMMAMNHGRFPDGTNGL HHHPAHRMGMGQFPSPHHHQ QQQPQHAFNALMGEHIHYGA GNMNATSGIRHAMGPGTVNG GHPPSALAPAARFNNSQFMG |
Function | Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor.interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis.potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP).stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region. |
Protein Name | Cbp/P300-Interacting Transactivator 2 Msg-Related Protein 1 Mrg-1 P35srj |
Database Links | Reactome: R-HSA-1234158 Reactome: R-HSA-8866906 Reactome: R-HSA-8866907 Reactome: R-HSA-9614657 |
Cellular Localisation | Nucleus Colocalizes With Ep300 In Dot-Like Structures |
Alternative Antibody Names | Anti-Cbp/P300-Interacting Transactivator 2 antibody Anti-Msg-Related Protein 1 antibody Anti-Mrg-1 antibody Anti-P35srj antibody Anti-CITED2 antibody Anti-MRG1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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