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  • 产品名称：Anti-CKAP4 antibody (130-400) (STJ110088)

  • 产品型号：STJ110088
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CKAP4 antibody (130-400) (STJ110088)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CKAP4 (130-400) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CKAP4
Gene ID: 10970
Uniprot ID: CKAP4_HUMAN
Immunogen Region: 130-400
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 130-400 of human CKAP4 (NP_006816.2).
Immunogen Sequence: VLEEVQQVRRSHQDFSRQRE ELGQGLQGVEQKVQSLQATF GTFESILRSSQHKQDLTEKA VKQGESEVSRISEVLQKLQN EILKDLSDGIHVVKDARERD FTSLENTVEERLTELTKSIN DNIAIFTEVQKRSQKEINDM KAKVASLEESEGNKQDLKAL KEAVKEIQTSAKSREWDMEA LRSTLQTMESDIYTEVRELV SLKQEQQAFKEAADTERLAL QALTEKLLRSEESVSRLPE
Post Translational Modifications Reversibly palmitoylated. Palmitoylation at Cys-100 by ZDHHC2 is required for its trafficking from the ER to the plasma membrane and for its perinuclear localization. Palmitoylation by ZDHHC2 is also required for its function in APF-mediated antiproliferative signaling. Increased phosphorylation during mitosis prevents binding to microtubules.
Function Mediates the anchoring of the endoplasmic reticulum to microtubules. High-affinity epithelial cell surface receptor for the FZD8-related low molecular weight sialoglycopeptide APF/antiproliferative factor. Mediates the APF antiproliferative signaling within cells.
Protein Name Cytoskeleton-Associated Protein 4
63-Kda Cytoskeleton-Linking Membrane Protein
Climp-63
P63
Database Links Reactome: R-HSA-381426
Reactome: R-HSA-5683826
Reactome: R-HSA-6798695
Reactome: R-HSA-8957275
Reactome: R-HSA-9696264
Reactome: R-HSA-9696270
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type Ii Membrane Protein
Cell Membrane
Cytoplasm
Cytoskeleton
Perinuclear Region
Translocates To The Perinuclear Region Upon Apf-Stimulation
Alternative Antibody Names Anti-Cytoskeleton-Associated Protein 4 antibody
Anti-63-Kda Cytoskeleton-Linking Membrane Protein antibody
Anti-Climp-63 antibody
Anti-P63 antibody
Anti-CKAP4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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