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  • 产品名称：Anti-CLCA1 antibody (22-150) (STJ117235)

  • 产品型号：STJ117235
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CLCA1 antibody (22-150) (STJ117235)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CLCA1 (22-150) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CLCA1
Gene ID: 1179
Uniprot ID: CLCA1_HUMAN
Immunogen Region: 22-150
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 22-150 of human CLCA1 (NP_001276.2).
Immunogen Sequence: NSLIQLNNNGYEGIVVAIDP NVPEDETLIQQIKDMVTQAS LYLFEATGKRFYFKNVAILI PETWKTKADYVRPKLETYKN ADVLVAESTPPGNDEPYTEQ MGNCGEKGERIHLTPDFIAG KKLAEYGPQ
Tissue Specificity Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the bronchial epithelium, especially in mucus-producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in.
Post Translational Modifications Glycosylated. The 125-kDa product is autoproteolytically processed by the metalloprotease domain and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37- to 41-kDa proteins. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.
Function May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
Protein Name Calcium-Activated Chloride Channel Regulator 1
Calcium-Activated Chloride Channel Family Member 1
Hclca1
Calcium-Activated Chloride Channel Protein 1
Cacc-1
Hcacc-1
Database Links Reactome: R-HSA-2672351
Cellular Localisation Secreted
Extracellular Space
Cell Membrane
Peripheral Membrane Protein
Extracellular Side
Protein That Remains Attached To The Plasma Membrane Appeared To Be Predominantly Localized To Microvilli
Alternative Antibody Names Anti-Calcium-Activated Chloride Channel Regulator 1 antibody
Anti-Calcium-Activated Chloride Channel Family Member 1 antibody
Anti-Hclca1 antibody
Anti-Calcium-Activated Chloride Channel Protein 1 antibody
Anti-Cacc-1 antibody
Anti-Hcacc-1 antibody
Anti-CLCA1 antibody
Anti-CACC1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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