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  • 产品名称：Anti-CBX5/HP1-Alpha antibody (Internal) (STJ70789)

  • 产品型号：STJ70789-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CBX5/HP1-Alpha antibody (Internal) (STJ70789)
详情介绍：
Host: Goat
Applications: Pep-ELISA/WB/IF/FC
Reactivity: Human/Mouse/Dog
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-CBX5/HP1-Alpha (Internal) is suitable for use in ELISA, Western Blot, Immunofluorescence and Flow Cytometry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.03-0.1µg/ml
IF-Strong expression of the protein seen in the nuclei of U2OS cells. 10µg/ml
FC-Flow cytometric analysis of HeLa cells. 10ug/ml
ELISA-antibody detection limit dilution 1:128000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: CBX5
Gene ID: 23468
Uniprot ID: CBX5_HUMAN
Immunogen Region: Internal
Accession Number: NP_036249.1; NP_001120793.1; NP_001120794.1
Specificity: Variants (NP_036249.1; NP_001120793.1; NP_001120794.1) encode the same protein.
Immunogen Sequence: NKRKSNFSNSADDIK
Function Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Protein Name Chromobox Protein Homolog 5
Antigen P25
Heterochromatin Protein 1 Homolog Alpha
Hp1 Alpha
Database Links Reactome: R-HSA-4551638
Reactome: R-HSA-8953750
Reactome: R-HSA-983231
Cellular Localisation Nucleus
Chromosome
Centromere
Colocalizes With Hnrnpu In The Nucleus
Component Of Centromeric And Pericentromeric Heterochromatin
Associates With Chromosomes During Mitosis
Associates Specifically With Chromatin During Metaphase And Anaphase
Localizes To Sites Of Dna Damage
Alternative Antibody Names Anti-Chromobox Protein Homolog 5 antibody
Anti-Antigen P25 antibody
Anti-Heterochromatin Protein 1 Homolog Alpha antibody
Anti-Hp1 Alpha antibody
Anti-CBX5 antibody
Anti-HP1A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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