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  • 产品名称：Human STK11 (Serine/Threonine Kinase 11) Sandwich ELISA Kit (STJE0012380)

  • 产品型号：STJE0012380
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human STK11 (Serine/Threonine Kinase 11) Sandwich ELISA Kit (STJE0012380)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.071ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This STK11 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: STK11
Gene ID: 6794
Uniprot ID: STK11_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Ubiquitously expressed. Strongest expression in testis and fetal liver.
Post Translational Modifications Phosphorylated by ATM at Thr-363 following ionizing radiation (IR). Phosphorylation at Ser-428 by RPS6KA1 and/or some PKA is required to inhibit cell growth. Phosphorylation at Ser-428 is also required during neuronal polarization to mediate phosphorylation of BRSK1 and BRSK2. Phosphorylation by PKC/PRKCZ at Ser-399 in isoform 2 promotes metformin (or peroxynitrite)-induced nuclear export of STK11 and activation of AMPK. UV radiation-induced phosphorylation at Thr-363 mediates CDKN1A degradation. Acetylated. Deacetylation at Lys-48 enhances cytoplasmic localization and kinase activity in vitro.
Function Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53.the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair. Isoform 2: Has a role in spermiogenesis.
Protein Name Serine/Threonine-Protein Kinase Stk11
Liver Kinase B1
Lkb1
Hlkb1
Renal Carcinoma Antigen Ny-Ren-19
Database Links Reactome: R-HSA-163680
Reactome: R-HSA-380972
Reactome: R-HSA-6804756
Reactome: R-HSA-9614657
Cellular Localisation Nucleus
Cytoplasm
Membrane
Mitochondrion
A Small Fraction Localizes At Membranes
Relocates To The Cytoplasm When Bound To Strad (Strada Or Stradb) And Cab39/Mo25 (Cab39/Mo25alpha Or Cab39l/Mo25beta)
Translocates To The Mitochondrion During Apoptosis
Pten Promotes Cytoplasmic Localization
Isoform 2: Nucleus
Predominantly Nuclear
But Translocates To The Cytoplasm In Response To Metformin Or Peroxynitrite Treatment
Alternative ELISA Names Serine/Threonine-Protein Kinase Stk11 ELISA kit
Liver Kinase B1 ELISA kit
Lkb1 ELISA kit
Hlkb1 ELISA kit
Renal Carcinoma Antigen Ny-Ren-19 ELISA kit
STK11 ELISA kit
LKB1 ELISA kit
PJS ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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