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  • 产品名称：Anti-CLDN1 antibody (112-211) [S4623RM] (STJ11104623)

  • 产品型号：STJ11104623
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CLDN1 antibody (112-211) [S4623RM] (STJ11104623)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Claudin-1 (112-211) is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Clone ID: S4623RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:5000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CLDN1
Gene ID: 9076
Uniprot ID: CLD1_HUMAN
Immunogen Region: 112-211
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 112-211 of human Claudin 1 (NP_066924.1).
Immunogen Sequence: EVQKMRMAVIGGAIFLLAGL AILVATAWYGNRIVQEFYDP MTPVNARYEFGQALFTGWAA ASLCLLGGALLCCSCPRKTT SYPTPRPYPKPAPSSGKDYV
Tissue Specificity Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.
Function Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions. (Microbial infection) Acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell. Acts as a receptor for dengue virus.
Protein Name Claudin-1
Senescence-Associated Epithelial Membrane Protein
Database Links Reactome: R-HSA-420029
Cellular Localisation Cell Junction
Tight Junction
Cell Membrane
Multi-Pass Membrane Protein
Basolateral Cell Membrane
Associates With Cd81 And The Cldn1-Cd81 Complex Localizes To The Basolateral Cell Membrane
Alternative Antibody Names Anti-Claudin-1 antibody
Anti-Senescence-Associated Epithelial Membrane Protein antibody
Anti-CLDN1 antibody
Anti-CLD1 antibody
Anti-SEMP1 antibody
Anti-UNQ481 antibody
Anti-PRO944 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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