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  • 产品名称：Human SYNPO2 (Synaptopodin 2) Sandwich ELISA Kit (STJE0012411)

  • 产品型号：STJE0012411
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human SYNPO2 (Synaptopodin 2) Sandwich ELISA Kit (STJE0012411)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.127ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This SYNPO2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: SYNPO2
Gene ID: 171024
Uniprot ID: SYNP2_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in heart muscle. Isoform 5 is specifically expressed in skeletal muscle.
Post Translational Modifications Phosphorylated by PKA, and by CaMK2 at multiple sites. Dephosphorylated by calcineurin.abrogating interaction with YWHAB and impairing nuclear import. Phosphorylated by ILK.
Function Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner. At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension.may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes. Involved in regulation of cell migration. May be a tumor suppressor. Isoform 1: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. Isoform 2: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. Isoform 3: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. Isoform 4: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. Isoform 5: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade.can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia. Can induce formation of thick, irregular actin bundles in the cell body.the induced actin network is associated with enhanced cell migration in vitro.
Protein Name Synaptopodin-2
Genethonin-2
Myopodin
Database Links
Cellular Localisation Nucleus
Cytoplasm
Cytoskeleton
Myofibril
Sarcomere
Z Line
Cell Junction
Focal Adhesion
Shuttles Between The Nucleus And The Cytoplasm In A Differentiation-Dependent And Stress-Induced Fashion
In Undifferentiated Myoblasts Strongly Expressed In The Nucleus
After Induction Of Myotube Differentiation Is Located To Both Nucleus And Cytoplasm Along Acting Filaments
And In Differentiated Myotubes Is Located At The Z Lines
Upon Stress Redistributes From Cytoplasm Of Myoblasts And Myotubes To The Nucleus
Nuclear Import Is Kpna2-Dependent And Promoted By Phosphorylation By Pka And/Or Camk2
And Inhibition Of Calcineurin
The Nuclear Export Is Xpo1-Dependent
Localized In A Fiber-Like Pattern
Partly Overlapping With Filamentous Actin
Isoform 1: Cytoplasm
Localizes To Induced Actin Bundles With Contiguous Staining
Isoform 2: Cytoplasm
Localizes To Induced Actin Bundles With Punctuate Staining
Isoform 3: Cytoplasm
Localizes To Induced Irregular Actin Bundles With Contiguous And Punctuated Staining
Isoform 4: Cytoplasm
Isoform 5: Cytoplasm
Alternative ELISA Names Synaptopodin-2 ELISA kit
Genethonin-2 ELISA kit
Myopodin ELISA kit
SYNPO2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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