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  • 产品名称：Human TLR5 (Toll Like Receptor 5) Sandwich ELISA Kit (STJE0012638)

  • 产品型号：STJE0012638
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human TLR5 (Toll Like Receptor 5) Sandwich ELISA Kit (STJE0012638)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.135ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This TLR5 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: TLR5
Gene ID: 7100
Uniprot ID: TLR5_HUMAN
Sample Type: tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity Highly expressed on the basolateral surface of intestinal epithelia. Expressed also in other cells such as lung epithelial cells.
Post Translational Modifications Phosphorylated at Ser-805 by PKD/PRKD1.phosphorylation induces the production of inflammatory cytokines. Phosphorylated at Tyr-798 upon flagellin binding.required for signaling.
Function Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response. Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota. Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response. Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life.
Protein Name Toll-Like Receptor 5
Toll/Interleukin-1 Receptor-Like Protein 3
Database Links Reactome: R-HSA-168176
Reactome: R-HSA-5602680
Reactome: R-HSA-5603037
Reactome: R-HSA-975871
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative ELISA Names Toll-Like Receptor 5 ELISA kit
Toll/Interleukin-1 Receptor-Like Protein 3 ELISA kit
TLR5 ELISA kit
TIL3 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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