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  • 产品名称：Anti-CLTRN antibody (STJA0008785)

  • 产品型号：STJA0008785
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CLTRN antibody (STJA0008785)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Collectrin is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CLTRN
Gene ID: 57393
Uniprot ID: CLTRN_HUMAN
Specificity: This antibody detects endogenous levels of TMEM27 at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human TMEM27
Post Translational Modifications Glycosylated. Glycosylation is required for plasma membrane localization and for its cleavage by BACE2. Proteolytically processed in pancreatic beta cells by BACE2 leading to the generation and extracellular release of soluble CLTRN, and a corresponding cell-associated C-terminal fragment which is later cleaved by gamma-secretase. This shedding process inactivates CLTRN. Three cleavage sites have been identified for BACE2, two clustered sites after Phe-116 and Leu-118 and a more membrane proximal site at Phe-125.the preferred BACE2 cleavage site seems to be between Phe-125 and Leu-126, Phe-116 and Leu-118 act as alternative sites.
Function Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their amino acid transporter activity. May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane. Regulator of SNARE complex function. Stimulator of beta cell replication.
Protein Name Collectrin
Transmembrane Protein 27
Database Links Reactome: R-HSA-264876
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Localizes To The Brush Border Membranes Of Cells In The Proximal Tubules Of Kidney
Colocalizes With Slc6a19 In The Early Proximal S1 Tubule
Alternative Antibody Names Anti-Collectrin antibody
Anti-Transmembrane Protein 27 antibody
Anti-CLTRN antibody
Anti-TMEM27 antibody
Anti-UNQ679 antibody
Anti-PRO1312 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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