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  • 产品名称：Anti-CMTM6 antibody (84-183) [S4263RM] (STJ11104263)

  • 产品型号：STJ11104263
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CMTM6 antibody (84-183) [S4263RM] (STJ11104263)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Cklf-Like Marvel Transmembrane Domain-Containing Protein 6 (84-183) is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Clone ID: S4263RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:2000-1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CMTM6
Gene ID: 54918
Uniprot ID: CKLF6_HUMAN
Immunogen Region: 84-183
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 84-183 of human CMTM6 (NP_060271.1).
Immunogen Sequence: LILIVYCTPFYERVDTTKVK SSDFYITLGTGCVFLLASII FVSTHDRTSAEIAAIVFGFI ASFMFLLDFITMLYEKRQES QLRKPENTTRAEALTEPLNA
Tissue Specificity Expressed in the leukocytes, placenta and testis.
Function Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.
Protein Name Cklf-Like Marvel Transmembrane Domain-Containing Protein 6
Chemokine-Like Factor Superfamily Member 6
Database Links Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Early Endosome Membrane
Recycling Endosome Membrane
Co-Localizes With Pd-L1/Cd274 In The Plasma Membrane And In Recycling Endosomes
Alternative Antibody Names Anti-Cklf-Like Marvel Transmembrane Domain-Containing Protein 6 antibody
Anti-Chemokine-Like Factor Superfamily Member 6 antibody
Anti-CMTM6 antibody
Anti-CKLFSF6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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