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  • 产品名称：Anti-CNOT1 antibody (STJA0006740)

  • 产品型号：STJA0006740
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CNOT1 antibody (STJA0006740)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CCR4-NOT transcription complex subunit 1 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CNOT1
Gene ID: 23019
Uniprot ID: CNOT1_HUMAN
Specificity: This antibody detects endogenous levels of CNOT1 at Human, Mouse
Immunogen: Synthesized peptide derived from human CNOT1
Function Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity.
Protein Name Ccr4-Not Transcription Complex Subunit 1
Ccr4-Associated Factor 1
Negative Regulator Of Transcription Subunit 1 Homolog
Not1h
Hnot1
Database Links Reactome: R-HSA-429947
Reactome: R-HSA-6804115
Cellular Localisation Cytoplasm
P-Body
Nucleus
Nanos2 Promotes Its Localization To P-Body
Alternative Antibody Names Anti-Ccr4-Not Transcription Complex Subunit 1 antibody
Anti-Ccr4-Associated Factor 1 antibody
Anti-Negative Regulator Of Transcription Subunit 1 Homolog antibody
Anti-Not1h antibody
Anti-Hnot1 antibody
Anti-CNOT1 antibody
Anti-CDC39 antibody
Anti-KIAA1007 antibody
Anti-NOT1 antibody
Anti-AD-005 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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