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  • 产品名称：Human TRPV1 (Transient Receptor Potential Cation Channel Subfamily V, Member 1) Sandwich ELISA Kit (STJE0012825)

  • 产品型号：STJE0012825
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human TRPV1 (Transient Receptor Potential Cation Channel Subfamily V, Member 1) Sandwich ELISA Kit (STJE0012825)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.112ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This TRPV1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: TRPV1
Gene ID: 7442
Uniprot ID: TRPV1_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).
Post Translational Modifications Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phosphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PRKCE, PRKCM and probably PRKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity.
Function Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly="" activate="" the="" channel.="" can="" be="" activated="" by="" endogenous="" compounds,="" including="" 12-hydroperoxytetraenoic="" acid="" and="" bradykinin.="" acts="" as="" ionotropic="" endocannabinoid="" receptor="" with="" central="" neuromodulatory="" effects.="" triggers="" a="" form="" of="" long-term="" depression="" (trpv1-ltd)="" mediated="" anandamine="" in="" hippocampus="" nucleus="" accumbens="" affecting="" ampa="" receptors="" endocytosis.="" <="" td="">
Protein Name Transient Receptor Potential Cation Channel Subfamily V Member 1
Trpv1
Capsaicin Receptor
Osm-9-Like Trp Channel 1
Otrpc1
Vanilloid Receptor 1
Database Links Reactome: R-HSA-3295583
Cellular Localisation Postsynaptic Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Dendritic Spine Membrane
Cell Membrane
Mostly
But Not Exclusively Expressed In Postsynaptic Dendritic Spines
Alternative ELISA Names Transient Receptor Potential Cation Channel Subfamily V Member 1 ELISA kit
Trpv1 ELISA kit
Capsaicin Receptor ELISA kit
Osm-9-Like Trp Channel 1 ELISA kit
Otrpc1 ELISA kit
Vanilloid Receptor 1 ELISA kit
TRPV1 ELISA kit
VR1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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