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  • 产品名称：Anti-CNOT3 antibody (STJA0007308)

  • 产品型号：STJA0007308
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CNOT3 antibody (STJA0007308)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CCR4-NOT transcription complex subunit 3 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CNOT3
Gene ID: 4849
Uniprot ID: CNOT3_HUMAN
Specificity: This antibody detects endogenous levels of CNOT3 at Human, Mouse
Immunogen: Synthesized peptide derived from human CNOT3
Function Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation.may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation.the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.
Protein Name Ccr4-Not Transcription Complex Subunit 3
Ccr4-Associated Factor 3
Leukocyte Receptor Cluster Member 2
Database Links Reactome: R-HSA-429947
Reactome: R-HSA-6804115
Cellular Localisation Cytoplasm
Nucleus
P-Body
Nanos2 Promotes Its Localization To P-Body
Alternative Antibody Names Anti-Ccr4-Not Transcription Complex Subunit 3 antibody
Anti-Ccr4-Associated Factor 3 antibody
Anti-Leukocyte Receptor Cluster Member 2 antibody
Anti-CNOT3 antibody
Anti-KIAA0691 antibody
Anti-LENG2 antibody
Anti-NOT3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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