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  • 产品名称：Anti-CNOT8 antibody (1-292) (STJ110361)

  • 产品型号：STJ110361
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CNOT8 antibody (1-292) (STJ110361)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CNOT8 (1-292) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CNOT8
Gene ID: 9337
Uniprot ID: CNOT8_HUMAN
Immunogen Region: 1-292
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-292 of human CNOT8 (NP_004770.4).
Immunogen Sequence: MPAALVENSQVICEVWASNL EEEMRKIREIVLSYSYIAMD TEFPGVVVRPIGEFRSSIDY QYQLLRCNVDLLKIIQLGLT FTNEKGEYPSGINTWQFNFK FNLTEDMYSQDSIDLLANSG LQFQKHEEEGIDTLHFAELL MTSGVVLCDNVKWLSFHSGY DFGYMVKLLTDSRLPEEEHE FFHILNLFFPSIYDVKYLMK SCKNLKGGLQEVADQLDLQR IGRQHQAGSDSLLTGMAFF
Function Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
Protein Name Ccr4-Not Transcription Complex Subunit 8
Caf1-Like Protein
Califp
Caf2
Ccr4-Associated Factor 8
Caf1b
Database Links Reactome: R-HSA-429947
Reactome: R-HSA-6804115
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-Ccr4-Not Transcription Complex Subunit 8 antibody
Anti-Caf1-Like Protein antibody
Anti-Califp antibody
Anti-Caf2 antibody
Anti-Ccr4-Associated Factor 8 antibody
Anti-Caf1b antibody
Anti-CNOT8 antibody
Anti-CALIF antibody
Anti-POP2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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