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  • 产品名称：Human VDR (Vitamin D3 receptor) CLIA Kit (STJC0000866)

  • 产品型号：STJC0000866
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human VDR (Vitamin D3 receptor) CLIA Kit (STJC0000866)
详情介绍：
Applications: CLIA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Sensitivity: 75pg/mL
Detection Limit: 125~8000pg/mL
Short Description: This human VDR kit is a highly sensitive in-vitro chemiluminescent immunoassay for the measurement of trace amounts of analytes.
Storage Instruction: If unopened the kit may be stored at 2-8°C for up to 1 month. If the kit will not be used within 1 month, store the components separately, according to the component table in the manual.
Assay Time: 3.5h
Detection: Chemiluminescence
Gene Symbol: VDR
Gene ID: 7421
Uniprot ID: VDR_HUMAN
Specificity: This kit recognizes Human VDR in samples. No significant cross-reactivity or interference between Human VDR and analogues was observed.
Sample Type: Serum, plasma and other biological fluids
Function Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Plays a central role in calcium homeostasis. Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites.
Protein Name Vitamin D3 Receptor
Vdr
1 -25-Dihydroxyvitamin D3 Receptor
Nuclear Receptor Subfamily 1 Group I Member 1
Database Links Reactome: R-HSA-196791
Reactome: R-HSA-383280
Reactome: R-HSA-4090294
Cellular Localisation Nucleus
Cytoplasm
Localizes Mainly To The Nucleus
Translocated Into The Nucleus Via Both Ligand-Dependent And Ligand-Independent Pathways
Ligand-Independent Nuclear Translocation Is Mediated By Ipo4
Alternative CLIA Names Vitamin D3 Receptor CLIA kit
Vdr CLIA kit
1 -25-Dihydroxyvitamin D3 Receptor CLIA kit
Nuclear Receptor Subfamily 1 Group I Member 1 CLIA kit
VDR CLIA kit
NR1I1 CLIA kit
Specificity This kit recognizes Human VDR in samples. No significant cross-reactivity or interference between Human VDR and analogues was observed.
Reproducibility Both intra-CV and inter-CV are

Information sourced from Uniprot.org


Item Specifications Storage
Micro CLIA Plate (Dismountable) 96T: 8 wells ×12 strips strips -20℃, 6 months
Reference Standard 96T: 2 vials 48T: 1 vial -20℃, 6 months
Concentrated Biotinylated Detection Ab (100×) 96T: 1 vial, 120 μL 60 μL -20℃, 6 months
Concentrated HRP Conjugate (100×) 96T: 1 vial, 120 μL 60 μL -20℃ (Protect from light), 6 months
Reference Standard & Sample Diluent 1 vial, 20 mL 2-8°C, 6 months
Biotinylated Detection Ab Diluent 1 vial, 14 mL 2-8°C, 6 months
HRP Conjugate Diluent 1 vial, 14 mL 2-8°C, 6 months
Concentrated Wash Buffer (25×) 1 vial, 30 mL 2-8°C, 6 months
Substrate Reagent A 1 vial, 5 mL 2-8℃ (Protect from light)
Substrate Reagent B 1 vial, 5 mL 2-8℃ (Protect from light)
Plate Sealer 5 pieces
Manual 1 copy
Certificate of Analysis 1 copy

Sample Type Range (%) Average Recovery (%)
Serum(n=8) 86-99 91
EDTA plasma(n=8) 86-97 91
Cell culture media(n=8) 93-109 99

Intra-assay Precision Intra-assay Precision Intra-assay Precision Inter-assay Precision Inter-assay Precision Inter-assay Precision
Sample 1.00 2.00 3.00 1.00 2.00 3.00
n 20.00 20.00 20.00 20.00 20.00 20.00
Mean (pg/mL) 394.38 844.69 2809.83 432.84 805.20 2605.02
Standard deviation 46.10 75.01 303.74 47.66 91.87 222.21
CV (%) 11.69 8.88 10.81 11.01 11.41 8.53
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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