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  • 产品名称：Human VMAT2 (Vesicular Monoamine Transporter 2) Sandwich ELISA Kit Ready-To-Use (STJE0019447)

  • 产品型号：STJE0019447
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human VMAT2 (Vesicular Monoamine Transporter 2) Sandwich ELISA Kit Ready-To-Use (STJE0019447)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.063ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This VMAT2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: SLC18A2
Gene ID: 6571
Uniprot ID: VMAT2_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Expressed in neuronal and neuroendocrine tissues. Detected in central and peripheral nervous system in particular in axonal and dendritic processes in dopaminergic cells of substantia nigra, histaminergic neuronal cell bodies of substantia nigra and tuberomammillary nucleus, in ganglion cells of sympathetic glia and in peripheral sympathetic nerve terminals in stomach and duodenum (at protein level). Highly expressed in chromaffin cells of the adrenal medulla and histamine-storing enterochromaffin-like cells of oxyntic mucosa (at protein level).
Post Translational Modifications
Function Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin. Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals. Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft. Responsible for histamine and serotonin storage and subsequent corelease from mast cell granules.
Protein Name Synaptic Vesicular Amine Transporter
Monoamine Transporter
Solute Carrier Family 18 Member 2
Vesicular Amine Transporter 2
Vat2
Database Links Reactome: R-HSA-181429
Reactome: R-HSA-181430
Reactome: R-HSA-212676
Reactome: R-HSA-442660
Cellular Localisation Cytoplasmic Vesicle
Secretory Vesicle
Synaptic Vesicle Membrane
Multi-Pass Membrane Protein
Secretory Vesicle Membrane
Cell Projection
Axon
Dendrite
Sorted To Large Dense Core Granules In Neuroendocrine Cells
Presumably At The Level Of The Trans-Golgi Network
In Neurons It Is Predominantly Detected In Somatodendritic Tubulovesicular Membranes
A Distinct Population Of Secretory Vesicles That Undergo Calcium-Dependent Exocytosis In Axons And Dendrites Upon Depolarization
Localized At Synaptic Vesicles In Axons
Alternative ELISA Names Synaptic Vesicular Amine Transporter ELISA kit
Monoamine Transporter ELISA kit
Solute Carrier Family 18 Member 2 ELISA kit
Vesicular Amine Transporter 2 ELISA kit
Vat2 ELISA kit
SLC18A2 ELISA kit
SVMT ELISA kit
VMAT2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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