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  • 产品名称：Anti-COLEC12 antibody (60-270) (STJ112454)

  • 产品型号：STJ112454
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-COLEC12 antibody (60-270) (STJ112454)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-COLEC12 (60-270) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: COLEC12
Gene ID: 81035
Uniprot ID: COL12_HUMAN
Immunogen Region: 60-270
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 60-270 of human COLEC12 (NP_569057.1).
Immunogen Sequence: KVVEKMDNVTGGMETSRQTY DDKLTAVESDLKKLGDQTGK KAISTNSELSTFRSDILDLR QQLREITEKTSKNKDTLEKL QASGDALVDRQSQLKETLEN NSFLITTVNKTLQAYNGYVT NLQQDTSVLQGNLQNQMYSH NVVIMNLNNLNLTQVQQRNL ITNLQRSVDDTSQAIQRIKN DFQNLQQVFLQAKKDTDWLK EKVQSLQTLAA
Tissue Specificity Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient.
Function Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease.
Protein Name Collectin-12
Collectin Placenta Protein 1
Cl-P1
Hcl-P1
Nurse Cell Scavenger Receptor 2
Scavenger Receptor Class A Member 4
Scavenger Receptor With C-Type Lectin
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-3000480
Cellular Localisation Membrane
Single-Pass Type Ii Membrane Protein
Forms Clusters On The Cell Surface
Alternative Antibody Names Anti-Collectin-12 antibody
Anti-Collectin Placenta Protein 1 antibody
Anti-Cl-P1 antibody
Anti-Hcl-P1 antibody
Anti-Nurse Cell Scavenger Receptor 2 antibody
Anti-Scavenger Receptor Class A Member 4 antibody
Anti-Scavenger Receptor With C-Type Lectin antibody
Anti-COLEC12 antibody
Anti-CLP1 antibody
Anti-NSR2 antibody
Anti-SCARA4 antibody
Anti-SRCL antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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