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  • 产品名称：Anti-COPB1 antibody (865-915 aa) (STJ192922)

  • 产品型号：STJ192922
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-COPB1 antibody (865-915 aa) (STJ192922)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Coatomer subunit beta (865-915 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: COPB1
Gene ID: 1315
Uniprot ID: COPB_HUMAN
Immunogen Region: 865-915 aa
Specificity: COPB Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein at the amino acid range 865-915
Function The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins.the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis. Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Promotes degradation of Nef cellular targets CD4 and MHC class I antigens by facilitating their trafficking to degradative compartments.
Protein Name Coatomer Subunit Beta
Beta-Coat Protein
Beta-Cop
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-6807878
Reactome: R-HSA-6811434
Cellular Localisation Cytoplasm
Golgi Apparatus Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cytoplasmic Vesicle
Copi-Coated Vesicle Membrane
Cell Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment
The Coatomer Is Cytoplasmic Or Polymerized On The Cytoplasmic Side Of The Golgi
As Well As On The Vesicles/Buds Originating From It
Proteolytic Cleavage By Capn8 Triggers Translocation From Golgi To Cytoplasm
Found In Perinuclear Vesicular-Tubular Clusters (Vtcs) And In The Golgi Region Where Associated With Vesicles
Buds And Rims Of The Golgi Stack
Occasionally Present At The Trans-Side Of Golgi
But Mainly Present At The Cis-Golgi Side In Transitional Areas (Ta)
On So-Called Peripheral Elements (Pe) Consisting Of Tubules And Vesicles Located Between The Cup-Shaped Transitional Elements (Te) Of The Rough Endoplasmic Reticulum (Rer) And The Cis-Most Golgi Cisternae
Present In Cytoplasm
Not Associated With Visible Coats Or Membranes
With A Minor Fraction Present On Small Clusters Of Tubules And Vesicles
Some Association With High-Density And Low-Density Microsomes And Mitochondria/Nuclei Fraction
Very Little Found In Plasma Membrane Fraction
Alternative Antibody Names Anti-Coatomer Subunit Beta antibody
Anti-Beta-Coat Protein antibody
Anti-Beta-Cop antibody
Anti-COPB1 antibody
Anti-COPB antibody
Anti-MSTP026 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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