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  • 产品名称：Anti-COPS3 antibody (320-423) [S4MR] (STJ11103044)

  • 产品型号：STJ11103044
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-COPS3 antibody (320-423) [S4MR] (STJ11103044)
详情介绍：
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-COPS3 (320-423) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: S4MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: COPS3
Gene ID: 8533
Uniprot ID: CSN3_HUMAN
Immunogen Region: 320-423
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 320-423 of human COPS3 (Q9UNS2).
Immunogen Sequence: QDMASRVQLSGPQEAEKYVL HMIEDGEIFASINQKDGMVS FHDNPEKYNNPAMLHNIDQE MLKCIELDERLKAMDQEITV NPQFVQKSMGSQEDDSGNKP SSYS
Tissue Specificity Widely expressed. Expressed at high level in heart and skeletal muscle.
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Protein Name Cop9 Signalosome Complex Subunit 3
Sgn3
Signalosome Subunit 3
Jab1-Containing Signalosome Subunit 3
Database Links Reactome: R-HSA-5696394
Reactome: R-HSA-6781823
Reactome: R-HSA-8856825
Reactome: R-HSA-8951664
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-Cop9 Signalosome Complex Subunit 3 antibody
Anti-Sgn3 antibody
Anti-Signalosome Subunit 3 antibody
Anti-Jab1-Containing Signalosome Subunit 3 antibody
Anti-COPS3 antibody
Anti-CSN3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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