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  • 产品名称：Anti-COPS7A antibody (STJ190725)

  • 产品型号：STJ190725
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-COPS7A antibody (STJ190725)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-COP9 signalosome complex subunit 7a is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: COPS7A
Gene ID: 50813
Uniprot ID: CSN7A_HUMAN
Specificity: CSN7A Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Post Translational Modifications Phosphorylated by CK2 and PKD kinases.
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Protein Name Cop9 Signalosome Complex Subunit 7a
Sgn7a
Signalosome Subunit 7a
Dermal Papilla-Derived Protein 10
Jab1-Containing Signalosome Subunit 7a
Database Links Reactome: R-HSA-5696394
Reactome: R-HSA-6781823
Reactome: R-HSA-8856825
Reactome: R-HSA-8951664
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-Cop9 Signalosome Complex Subunit 7a antibody
Anti-Sgn7a antibody
Anti-Signalosome Subunit 7a antibody
Anti-Dermal Papilla-Derived Protein 10 antibody
Anti-Jab1-Containing Signalosome Subunit 7a antibody
Anti-COPS7A antibody
Anti-CSN7A antibody
Anti-DERP10 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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