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  • 产品名称：Anti-CRACR2A antibody (STJA0007299)

  • 产品型号：STJA0007299
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CRACR2A antibody (STJA0007299)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-EF-hand calcium-binding domain-containing protein 4B is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CRACR2A
Gene ID: 84766
Uniprot ID: EFC4B_HUMAN
Specificity: This antibody detects endogenous levels of CRACR2A at Human, Mouse
Immunogen: Synthesized peptide derived from human CRACR2A
Function Isoform 1: Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. Isoform 2: Rab GTPase that mediates the trafficking of Weibel-Palade bodies (WPBs) to microtubule organizing center (MTOC) in endothelial cells in response to acute inflammatory stimuli. During histamine (but not thrombin) stimulation of endothelial cells, the dynein-bound form induces retrograde transport of a subset of WPBs along microtubules to the MTOC in a Ca(2+)-independent manner and its GTPase activity is essential for this function. Ca(2+)-regulated dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules and regulates endosomal trafficking of CD47. Acts as an intracellular signaling module bridging two important T-cell receptor (TCR) signaling pathways, Ca(2+)-NFAT and JNK, to affect T-cell activation. In resting T-cells, is predominantly localized near TGN network in a GTP-bound form, upon TCR stimulation, localizes at the immunological synapse via interaction with VAV1 to activate downstream Ca(2+)-NFAT and JNK signaling pathways. Plays a role in T-helper 1 (Th1) cell differentiation and T-helper 17 (Th17) cell effector function. Plays a role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation.
Protein Name Ef-Hand Calcium-Binding Domain-Containing Protein 4b
Calcium Release-Activated Calcium Channel Regulator 2a
Crac Channel Regulator 2a
Calcium Release-Activated Channel Regulator 2a
Ras-Related Protein Rab-46
Database Links Reactome: R-HSA-6798695
Cellular Localisation Isoform 1: Cytoplasm
Isoform 2: Cytoplasm
Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Cell Membrane
Golgi Apparatus Membrane
Golgi Apparatus
Trans-Golgi Network Membrane
Vesicle
T-Cell Activation-Induced Elevation Of Intracellular Of Ca(2+) Stimulates Its Transport Toward The Microtubule Organizing Center (Mtoc)
Histamine Stimulation Induces A Trafficking To The Mtoc In A Gtp-Binding-Dependent But Ca(2+)-Binding-Independent Manner
Localizes To Golgi Membrane In Resting T-Cells And Upon Its Interaction With Vav1
Is Translocated From The Golgi Membrane To The Immunological Synapse Via Subsynaptic Vesicles
Its Localization In The Golgi Membrane Requires Isoprenylation And Gtp-Binding
Alternative Antibody Names Anti-Ef-Hand Calcium-Binding Domain-Containing Protein 4b antibody
Anti-Calcium Release-Activated Calcium Channel Regulator 2a antibody
Anti-Crac Channel Regulator 2a antibody
Anti-Calcium Release-Activated Channel Regulator 2a antibody
Anti-Ras-Related Protein Rab-46 antibody
Anti-CRACR2A antibody
Anti-EFCAB4B antibody
Anti-RAB46 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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