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  • 产品名称：Anti-CRBN antibody (1-280) (STJ26824)

  • 产品型号：STJ26824
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CRBN antibody (1-280) (STJ26824)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CRBN (1-280) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CRBN
Gene ID: 51185
Uniprot ID: CRBN_HUMAN
Immunogen Region: 1-280
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human CRBN (NP_057386.2?).
Immunogen Sequence: MAGEGDQQDAAHNMGNHLPL LPAESEEEDEMEVEDQDSKE AKKPNIINFDTSLPTSHTYL GADMEEFHGRTLHDDDSCQV IPVLPQVMMILIPGQTLPLQ LFHPQEVSMVRNLIQKDRTF AVLAYSNVQEREAQFGTTAE IYAYREEQDFGIEIVKVKAI GRQRFKVLELRTQSDGIQQA KVQILPECVLPSTMSAVQLE SLNKCQIFPSKPVSREDQCS YKWWQKYQKRKFHCANLTS
Tissue Specificity Widely expressed. Highly expressed in brain.
Post Translational Modifications Ubiquitinated, ubiquitination is mediated by its own DCX protein ligase complex.
Function Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 or ILF2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1. May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism. Plays a negative role in TLR4 signaling by interacting with TRAF6 and ECSIT, leading to inhibition of ECSIT ubiquitination, an important step of the signaling.
Protein Name Protein Cereblon
Database Links Reactome: R-HSA-9679191
Cellular Localisation Cytoplasm
Nucleus
Membrane
Peripheral Membrane Protein
Alternative Antibody Names Anti-Protein Cereblon antibody
Anti-CRBN antibody
Anti-AD-006 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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