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  • 产品名称：Anti-CREB3L2 antibody (269-318 aa) (STJ92469)

  • 产品型号：STJ92469
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CREB3L2 antibody (269-318 aa) (STJ92469)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cyclic AMP-responsive element-binding protein 3-like protein 2 (269-318 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CREB3L2
Gene ID: 64764
Uniprot ID: CR3L2_HUMAN
Immunogen Region: 269-318 aa
Specificity: CREB3L2 Polyclonal Antibody detects endogenous levels of CREB3L2 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human CREB3L2 at the amino acid range 269-318
Post Translational Modifications Upon ER stress, translocated to the Golgi apparatus, where it is processed by regulated intramembrane proteolysis (RIP) to release the cytosol-facing N-terminal transcription factor domain. The cleavage is performed sequentially by site-1 and site-2 proteases (S1P/MBTPS1 and S2P/MBTPS2). N-glycosylated. Ubiquitinated by HRD1/SYVN1.undergoes 'Lys-48'-linked ubiquitination, followed by rapid proteasomal degradation under normal conditions. Upon ER stress, SYVN1 E3 ubiquitin-protein ligase dissociates from its substrate, ubiquitination does not occur and CREB3L2 is stabilized.
Function Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes. In a neuroblastoma cell line, protects cells from ER stress-induced death. In vitro activates transcription of target genes via direct binding to the CRE site.
Protein Name Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 2
Camp-Responsive Element-Binding Protein 3-Like Protein 2
Bbf2 Human Homolog On Chromosome 7 Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 2
Database Links Reactome: R-HSA-8874211
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type Ii Membrane Protein
Er Membrane Resident Protein
Upon Er Stress
Translocated To The Golgi Apparatus Where It Is Cleaved
The Cytosolic N-Terminal Fragment (Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 1) Is Transported Into The Nucleus
Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 2: Nucleus
Translocated Into The Nucleus
Alternative Antibody Names Anti-Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 2 antibody
Anti-Camp-Responsive Element-Binding Protein 3-Like Protein 2 antibody
Anti-Bbf2 Human Homolog On Chromosome 7 Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 2 antibody
Anti-CREB3L2 antibody
Anti-BBF2H7 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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