产品详情
简单介绍：
Anti-CREBBP antibody (900-1000) [PT0619] (STJA0006228)
详情介绍：
| Host: | Mouse |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-CREB-binding protein (900-1000) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: | Monoclonal |
| Clone ID: | PT0619 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2bk |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CREBBP |
| Gene ID: | 1387 |
| Uniprot ID: | CBP_HUMAN |
| Immunogen Region: | 900-1000 |
| Specificity: | This antibody detects endogenous levels of CREBBP at Human, Predict react with Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human CREBBP AA range: 900-1000 |
| Post Translational Modifications | Methylation of the KIX domain by CARM1 blocks association with CREB. This results in the blockade of CREB signaling, and in activation of apoptotic response. Phosphorylated by CHUK/IKKA at Ser-1382 and Ser-1386.these phosphorylations promote cell growth by switching the binding preference of CREBBP from TP53 to NF-kappa-B. Sumoylation negatively regulates transcriptional activity via the recruitment of DAAX. Autoacetylation is required for binding to protein substrates, such as acetylated histones and acetylated TP53/p53. Autoacetylation is induced by glucose and fatty acids. |
| Function | Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers. Acetylates PCNA.acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region. Acetylates DDX21, thereby inhibiting DDX21 helicase activity. Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway. |
| Protein Name | Creb-Binding Protein Histone Lysine Acetyltransferase Crebbp Protein-Lysine Acetyltransferase Crebbp |
| Database Links | Reactome: R-HSA-1234158 Reactome: R-HSA-1368082 Reactome: R-HSA-1368108 Reactome: R-HSA-1912408 Reactome: R-HSA-1989781 Reactome: R-HSA-201722 Reactome: R-HSA-210744 Reactome: R-HSA-2122947 Reactome: R-HSA-2151201 Reactome: R-HSA-2426168 Reactome: R-HSA-2644606 Reactome: R-HSA-2894862 Reactome: R-HSA-3134973 Reactome: R-HSA-3214847 Reactome: R-HSA-3371568 Reactome: R-HSA-350054 Reactome: R-HSA-381340 Reactome: R-HSA-3899300 Reactome: R-HSA-400206 Reactome: R-HSA-400253 Reactome: R-HSA-5617472 Reactome: R-HSA-5621575 Reactome: R-HSA-6803204 Reactome: R-HSA-8866907 Reactome: R-HSA-8939246 Reactome: R-HSA-8941856 Reactome: R-HSA-9013508 Reactome: R-HSA-9013695 Reactome: R-HSA-9018519 Reactome: R-HSA-918233 Reactome: R-HSA-933541 Reactome: R-HSA-9614657 Reactome: R-HSA-9617629 Reactome: R-HSA-9705671 Reactome: R-HSA-9707564 Reactome: R-HSA-9707616 Reactome: R-HSA-9759194 Reactome: R-HSA-9768919 Reactome: R-HSA-9793380 Reactome: R-HSA-9818027 Reactome: R-HSA-9818028 |
| Cellular Localisation | Cytoplasm Nucleus Recruited To Nuclear Bodies By Ss18l1/Crest In The Presence Of Alx1 Relocalizes From The Cytoplasm To The Nucleus |
| Alternative Antibody Names | Anti-Creb-Binding Protein antibody Anti-Histone Lysine Acetyltransferase Crebbp antibody Anti-Protein-Lysine Acetyltransferase Crebbp antibody Anti-CREBBP antibody Anti-CBP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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