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  • 产品名称：Anti-CRTC1 antibody [1B5] (STJ98426)

  • 产品型号：STJ98426
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CRTC1 antibody [1B5] (STJ98426)
详情介绍：
Host: Mouse
Applications: WB/IF/FC/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CREB-regulated transcription coactivator 1 is suitable for use in Western Blot, Immunofluorescence, Flow Cytometry and ELISA research applications.
Clonality: Monoclonal
Clone ID: 1B5
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF 1:200-1:1000
FC 1:200-1:400
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CRTC1
Gene ID: 23373
Uniprot ID: CRTC1_HUMAN
Specificity: TORC1 Monoclonal Antibody detects endogenous levels of TORC1 protein.
Immunogen: Purified recombinant fragment of human TORC1 expressed in E. Coli.
Post Translational Modifications Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1.
Function Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
Protein Name Creb-Regulated Transcription Coactivator 1
Mucoepidermoid Carcinoma Translocated Protein 1
Transducer Of Regulated Camp Response Element-Binding Protein 1
Torc-1
Transducer Of Creb Protein 1
Database Links Reactome: R-HSA-2151201
Reactome: R-HSA-400253
Reactome: R-HSA-9707616
Cellular Localisation Cytoplasm
Nucleus
Cytoplasmic When Phosphorylated By Sik Or Ampk And When Sequestered By 14-3-3 Proteins
Translocated To The Nucleus On Ser-151 Dephosphorylation
Instigated By A Number Of Factors Including Calcium Ion And Camp Levels
Light Stimulation Triggers A Nuclear Accumulation In The Suprachiasmatic Nucleus (Scn) Of The Brain
Alternative Antibody Names Anti-Creb-Regulated Transcription Coactivator 1 antibody
Anti-Mucoepidermoid Carcinoma Translocated Protein 1 antibody
Anti-Transducer Of Regulated Camp Response Element-Binding Protein 1 antibody
Anti-Torc-1 antibody
Anti-Transducer Of Creb Protein 1 antibody
Anti-CRTC1 antibody
Anti-KIAA0616 antibody
Anti-MECT1 antibody
Anti-TORC1 antibody
Anti-WAMTP1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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