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  • 产品名称：Anti-CRTC2 antibody (STJA0009924)

  • 产品型号：STJA0009924
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CRTC2 antibody (STJA0009924)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CREB-regulated transcription coactivator 2 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CRTC2
Gene ID: 200186
Uniprot ID: CRTC2_HUMAN
Specificity: This antibody detects endogenous levels of TORC2 Phospho-Ser171 at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human TORC2 Phospho-Ser171
Tissue Specificity Most abundantly expressed in the thymus. Present in both B and T-lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas.
Post Translational Modifications Phosphorylation/dephosphorylation states of Ser-171 are required for regulating transduction of CREB activity. CRTCs/TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation, is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs (SIK1 and SIK2) by LKB1. Following adenylyl cyclase activation, dephosphorylated at Ser-171 by PPP3CA/calcineurin A resulting in CRTC2 dissociation from 14-3-3 proteins and PPP3CA. Both insulin and AMPK increase this phosphorylation of CRTC2 while glucagon suppresses it. Phosphorylation at Ser-274 by MARK2 is induced under low glucose conditions and dephosphorylated in response to glucose influx. Phosphorylation at Ser-274 promotes interaction with 14-3-3 proteins and translocation to the cytoplasm. Asymmetric dimethylation of arginine resisues by PRMT6 enhances the association of CRTC2 with CREB on the promoters of gluconeogenic genes.
Function Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
Protein Name Creb-Regulated Transcription Coactivator 2
Transducer Of Regulated Camp Response Element-Binding Protein 2
Torc-2
Transducer Of Creb Protein 2
Database Links Reactome: R-HSA-2151201
Reactome: R-HSA-400253
Reactome: R-HSA-9707616
Cellular Localisation Cytoplasm
Nucleus
Translocated From The Nucleus To The Cytoplasm On Interaction Of The Phosphorylated Form With 14-3-3 Protein
In Response To Camp Levels And Glucagon
Relocated To The Nucleus
Alternative Antibody Names Anti-Creb-Regulated Transcription Coactivator 2 antibody
Anti-Transducer Of Regulated Camp Response Element-Binding Protein 2 antibody
Anti-Torc-2 antibody
Anti-Transducer Of Creb Protein 2 antibody
Anti-CRTC2 antibody
Anti-TORC2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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