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  • 产品名称：Anti-CRYAB antibody (1-175) (STJ115651)

  • 产品型号：STJ115651
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CRYAB antibody (1-175) (STJ115651)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CRYAB (1-175) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CRYAB
Gene ID: 1410
Uniprot ID: CRYAB_HUMAN
Immunogen Region: 1-175
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-175 of human CRYAB (NP_001876.1).
Immunogen Sequence: MDIAIHHPWIRRPFFPFHSP SRLFDQFFGEHLLESDLFPT STSLSPFYLRPPSFLRAPSW FDTGLSEMRLEKDRFSVNLD VKHFSPEELKVKVLGDVIEV HGKHEERQDEHGFISREFHR KYRIPADVDPLTITSSLSSD GVLTVNGPRKQVSGPERTIP ITREEKPAVTAAPKK
Tissue Specificity Lens as well as other tissues. Expressed in myocardial tissue.
Function May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome.
Protein Name Alpha-Crystallin B Chain
Alpha(B-Crystallin
Heat Shock Protein Beta-5
Hspb5
Renal Carcinoma Antigen Ny-Ren-27
Rosenthal Fiber Component
Database Links Reactome: R-HSA-3371571
Cellular Localisation Cytoplasm
Nucleus
Secreted
Lysosome
Translocates To The Nucleus During Heat Shock And Resides In Sub-Nuclear Structures Known As Sc35 Speckles Or Nuclear Splicing Speckles
Localizes At The Z-Bands And The Intercalated Disk In Cardiomyocytes
Can Be Secreted
The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10
It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion
Alternative Antibody Names Anti-Alpha-Crystallin B Chain antibody
Anti-Alpha(B-Crystallin antibody
Anti-Heat Shock Protein Beta-5 antibody
Anti-Hspb5 antibody
Anti-Renal Carcinoma Antigen Ny-Ren-27 antibody
Anti-Rosenthal Fiber Component antibody
Anti-CRYAB antibody
Anti-CRYA2 antibody
Anti-HSPB5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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