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  • 产品名称：Anti-CTNND1 antibody (600-700 aa) [ABT-p120] (STJ197036)

  • 产品型号：STJ197036
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CTNND1 antibody (600-700 aa) [ABT-p120] (STJ197036)
详情介绍：
Host: Mouse
Applications: WB/IHC/IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Catenin delta-1 (600-700 aa) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Monoclonal
Clone ID: ABT-p120
Conjugation: Unconjugated
Isotype: IgG2bk
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Dilution Range: IHC-P 1:100-500
WB 1:100-2000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CTNND1
Gene ID: 1500
Uniprot ID: CTND1_HUMAN
Immunogen Region: 600-700 aa
Specificity: This antibody detects endogenous levels of human p120 catenin. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH9.0 was highly recommended as antigen repair method in paraffin section
Immunogen: Synthesized peptide derived from the human p120 catenin at the amino acid range 600-700
Post Translational Modifications Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK5. Dephosphorylated by PTPRJ.
Function Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors.
Protein Name Catenin Delta-1
Cadherin-Associated Src Substrate
Cas
P120 Catenin
P120(Ctn
P120(Cas
Database Links Reactome: R-HSA-418990
Reactome: R-HSA-5218920
Reactome: R-HSA-8876493
Reactome: R-HSA-9762292
Reactome: R-HSA-9764302
Reactome: R-HSA-9833576
Cellular Localisation Cell Junction
Adherens Junction
Cytoplasm
Nucleus
Cell Membrane
Interaction With Glis2 Promotes Nuclear Translocation
Detected At Cell-Cell Contacts
Nanos1 Induces Its Translocation From Sites Of Cell-Cell Contact To The Cytoplasm
Cdh1 Enhances Cell Membrane Localization
Isoforms 4a And 1ab Are Excluded From The Nucleus
Isoform 1a: Nucleus
Isoform 2a: Nucleus
Isoform 3a: Nucleus
Alternative Antibody Names Anti-Catenin Delta-1 antibody
Anti-Cadherin-Associated Src Substrate antibody
Anti-Cas antibody
Anti-P120 Catenin antibody
Anti-P120(Ctn antibody
Anti-P120(Cas antibody
Anti-CTNND1 antibody
Anti-KIAA0384 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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