产品详情
查看大图

  • 产品名称：Mouse CCR2 (Chemokine C-C-Motif Receptor 2) Sandwich ELISA Kit (STJE0007773)

  • 产品型号：STJE0007773
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Mouse CCR2 (Chemokine C-C-Motif Receptor 2) Sandwich ELISA Kit (STJE0007773)
详情介绍：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.061ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This CCR2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Ccr2
Gene ID: 12772
Uniprot ID: CCR2_MOUSE
Sample Type: serum, plasma, tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Epressed in mature thymocytes. Detected in monocyte/macrophage cell lines, but not in nonhematopoietic cell lines.
Post Translational Modifications N-glycosylated. Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form. Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer.
Function Key functional receptor for CCL2 but can also bind CCL7 and CCL12 chemokines. Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion. Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B. Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation. Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression.signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. Mediates the recruitment of macrophages and monocytes to the injury site following brain injury.
Protein Name C-C Chemokine Receptor Type 2
C-C Ckr-2
Cc-Ckr-2
Ccr-2
Ccr2
Je/Fic Receptor
Mcp-1 Receptor
Cd Antigen Cd192
Database Links
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
The Chemoattractant Receptors Are Reportedly Distributed Throughout The Cell Surface
After Stimulation With A Ligand
Such As Ccl2
They Are Rapidly Recruited Into Microdomain Clusters At The Cell Membrane
Alternative ELISA Names C-C Chemokine Receptor Type 2 ELISA kit
C-C Ckr-2 ELISA kit
Cc-Ckr-2 ELISA kit
Ccr-2 ELISA kit
Ccr2 ELISA kit
Je/Fic Receptor ELISA kit
Mcp-1 Receptor ELISA kit
Cd Antigen Cd192 ELISA kit
Ccr2 ELISA kit
Cmkbr2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号