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  • 产品名称：Mouse CDK8 (Cyclin Dependent Kinase 8) Sandwich ELISA Kit (STJE0007856)

  • 产品型号：STJE0007856
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse CDK8 (Cyclin Dependent Kinase 8) Sandwich ELISA Kit (STJE0007856)
详情介绍：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.053ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This CDK8 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Cdk8
Gene ID: 264064
Uniprot ID: CDK8_MOUSE
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.
Protein Name Cyclin-Dependent Kinase 8
Cell Division Protein Kinase 8
Mediator Complex Subunit Cdk8
Mediator Of Rna Polymerase Ii Transcription Subunit Cdk8
Database Links Reactome: R-MMU-2173796
Cellular Localisation Nucleus
Alternative ELISA Names Cyclin-Dependent Kinase 8 ELISA kit
Cell Division Protein Kinase 8 ELISA kit
Mediator Complex Subunit Cdk8 ELISA kit
Mediator Of Rna Polymerase Ii Transcription Subunit Cdk8 ELISA kit
Cdk8 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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