产品详情
查看大图

  • 产品名称：Anti-CYP11B1 antibody (61-110 aa) (STJ96589)

  • 产品型号：STJ96589
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Anti-CYP11B1 antibody (61-110 aa) (STJ96589)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cytochrome P450 11B1, mitochondrial (61-110 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CYP11B1
Gene ID: 1584
Uniprot ID: C11B1_HUMAN
Immunogen Region: 61-110 aa
Specificity: CYP11B1/2 Polyclonal Antibody detects endogenous levels of CYP11B1/2 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the N-terminal region of human CYP11B1/2 at the amino acid range 61-110
Function A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes a variety of reactions that are essential for many species, including detoxification, defense, and the formation of endogenous chemicals like steroid hormones. Steroid 11beta, 18- and 19-hydroxylase with preferred regioselectivity at 11beta, then 18, and lastly 19. Catalyzes the hydroxylation of 11-deoxycortisol and 11-deoxycorticosterone (21-hydroxyprogesterone) at 11beta position, yielding cortisol or corticosterone, respectively, but cannot produce aldosterone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate for hydroxylation and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). Due to its lack of 18-oxidation activity, it is incapable of generating aldosterone. Could also be involved in the androgen metabolic pathway (Probable).
Protein Name Cytochrome P450 11b1 - Mitochondrial
Cyp11b1
Cypxib1
Cytochrome P-450c11
Cytochrome P450c11
Steroid 11-Beta-Hydroxylase - Cyp11b1
Database Links Reactome: R-HSA-194002
Reactome: R-HSA-211976
Reactome: R-HSA-5579017
Cellular Localisation Mitochondrion Inner Membrane
Peripheral Membrane Protein
Alternative Antibody Names Anti-Cytochrome P450 11b1 - Mitochondrial antibody
Anti-Cyp11b1 antibody
Anti-Cypxib1 antibody
Anti-Cytochrome P-450c11 antibody
Anti-Cytochrome P450c11 antibody
Anti-Steroid 11-Beta-Hydroxylase - Cyp11b1 antibody
Anti-CYP11B1 antibody
Anti-S11BH antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号