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  • 产品名称：Anti-CERS2 antibody (55-125) (STJ11100193)

  • 产品型号：STJ11100193
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CERS2 antibody (55-125) (STJ11100193)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CERS2 (55-125) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CERS2
Gene ID: 29956
Uniprot ID: CERS2_HUMAN
Immunogen Region: 55-125
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 55-125 of human CERS2 (NP_071358.1).
Immunogen Sequence: FFELYVATPLAALLNIKEKT RLRAPPNATLEHFYLTSGKQ PKQVEVELLSRQSGLSGRQV ERWFRRRRNQD
Tissue Specificity Expressed in kidney, liver, brain, heart, placenta and lung.
Post Translational Modifications Acetylated. Deacetylation by SIRT3 increases enzyme activity and promotes mitochondrial ceramide accumulation. Phosphorylated at the C-terminus by CK2, leading to increase the ceramide synthase activity.
Function Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very-long-chain fatty acyl-CoA (chain length C22-C27). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Plays a non-redundant role in the synthesis of ceramides with very-long-chain fatty acids in kidney, liver and brain. Regulates the abundance of myelin-specific sphingolipids galactosylceramide and sulfatide that affects myelin sheath architecture and motor neuron functions.
Protein Name Ceramide Synthase 2
Cers2
Lag1 Longevity Assurance Homolog 2
Sp260
Sphingosine N-Acyltransferase Cers2
Tumor Metastasis-Suppressor Gene 1 Protein
Very-Long-Chain Ceramide Synthase Cers2
Database Links Reactome: R-HSA-1660661
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Ceramide Synthase 2 antibody
Anti-Cers2 antibody
Anti-Lag1 Longevity Assurance Homolog 2 antibody
Anti-Sp260 antibody
Anti-Sphingosine N-Acyltransferase Cers2 antibody
Anti-Tumor Metastasis-Suppressor Gene 1 Protein antibody
Anti-Very-Long-Chain Ceramide Synthase Cers2 antibody
Anti-CERS2 antibody
Anti-LASS2 antibody
Anti-TMSG1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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