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  • 产品名称：Anti-CHST1 antibody (62-411) (STJ115024)

  • 产品型号：STJ115024
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CHST1 antibody (62-411) (STJ115024)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CHST1 (62-411) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CHST1
Gene ID: 8534
Uniprot ID: CHST1_HUMAN
Immunogen Region: 62-411
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 62-411 of human CHST1 (NP_003645.1).
Immunogen Sequence: HILILATTRSGSSFVGQLFN QHLDVFYLFEPLYHVQNTLI PRFTQGKSPADRRVMLGASR DLLRSLYDCDLYFLENYIKP PPVNHTTDRIFRRGASRVLC SRPVCDPPGPADLVLEEGDC VRKCGLLNLTVAAEACRERS HVAIKTVRVPEVNDLRALVE DPRLNLKVIQLVRDPRGILA SRSETFRDTYRLWRLWYGTG RKPYNLDVTQLTTVCEDFSN SVSTGLMRPPWLKGKYMLV
Tissue Specificity Widely expressed at low level. Expressed in brain and skeletal muscle. Expressed by high endothelial cells (HEVs) and leukocytes.
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of internal galactose (Gal) residues of keratan. Cooperates with B4GALT4 and B3GNT7 glycosyltransferases and CHST6 sulfotransferase to construct and elongate disulfated disaccharide unit ->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1-> within keratan sulfate polymer. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. Involved in biosynthesis of phosphacan, a major keratan sulfate proteoglycan in the developing brain. Involved in biosynthesis of 6-sulfoGalbeta-containing O-linked glycans in high endothelial venules of lymph nodes. May act in a synergistic manner with CHST4 to generate sialyl 6',6-disulfo Lewis X motif, a recognition determinant for immune cell receptors implicated in leukocyte trafficking. Catalyzes sulfation of N-acetyllactosamine (LacNAc) oligosaccharides with highest efficiency for sialylated LacNAc structures.
Protein Name Carbohydrate Sulfotransferase 1
Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 1
Gst-1
Keratan Sulfate Gal-6 Sulfotransferase
Ks6st
Ksgal6st
Ksst
Database Links Reactome: R-HSA-2022854
Cellular Localisation Golgi Apparatus Membrane
Single-Pass Type Ii Membrane Protein
Alternative Antibody Names Anti-Carbohydrate Sulfotransferase 1 antibody
Anti-Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 1 antibody
Anti-Gst-1 antibody
Anti-Keratan Sulfate Gal-6 Sulfotransferase antibody
Anti-Ks6st antibody
Anti-Ksgal6st antibody
Anti-Ksst antibody
Anti-CHST1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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