产品详情
简单介绍:
Anti-Cleaved-KNG1-K380 antibody (300-380 aa) (STJ90095)
详情介绍:
Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human/Rat/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Cleaved-Kininogen-1-K380 (300-380 aa) is suitable for use in Western Blot and ELISA research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-1:2000 ELISA 1:10000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | KNG1 |
Gene ID: | 3827 |
Uniprot ID: | KNG1_HUMAN |
Immunogen Region: | 300-380 aa |
Specificity: | Cleaved-Kininogen-1 HC (K380) Polyclonal Antibody detects endogenous levels of fragment of activated Kininogen-1 HC protein resulting from cleavage adjacent to K380. |
Immunogen: | Synthesized peptide derived from Cleaved-Kininogen-1 HC (K380) at the amino acid range 300-380 |
Post Translational Modifications | Bradykinin: Bradykinin is inactivated by ACE, which removes the dipeptide Arg-Phe from its C-terminus. Bradykinin is released from kininogen by plasma kallikrein. Hydroxylation of Pro-383 occurs prior to the release of bradykinin. Phosphorylated by FAM20C in the extracellular medium. N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. (Microbial infection) Bradykinin is generated upon proteolytic cleavage by S.pyogenes SpeB to produce hypotension during septic shock. |
Function | Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII.HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. Bradykinin: The active peptide bradykinin is a potent vasodilatator that is released from HMW-kininogen shows a variety of physiological effects: (A) influence in smooth muscle contraction, (B) induction of hypotension, (C) natriuresis and diuresis, (D) decrease in blood glucose level, (E) it is a mediator of inflammation and causes (E1) increase in vascular permeability, (E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action). |
Protein Name | Kininogen-1 Alpha-2-Thiol Proteinase Inhibitor Fitzgerald Factor High Molecular Weight Kininogen Hmwk Williams-Fitzgerald-Flaujeac Factor Cleaved Into - Kininogen-1 Heavy Chain - T-Kinin Ile-Ser-Bradykinin - Bradykinin Kallidin I - Lysyl-Bradykinin Kallidin Ii - Kininogen-1 Light Chain - Low Molecular Weight Growth-Promoting Factor |
Database Links | Reactome: R-HSA-114608 Reactome: R-HSA-140837 Reactome: R-HSA-375276 Reactome: R-HSA-381426 Reactome: R-HSA-416476 Reactome: R-HSA-418594 Reactome: R-HSA-8957275 |
Cellular Localisation | Secreted Extracellular Space |
Alternative Antibody Names | Anti-Kininogen-1 antibody Anti-Alpha-2-Thiol Proteinase Inhibitor antibody Anti-Fitzgerald Factor antibody Anti-High Molecular Weight Kininogen antibody Anti-Hmwk antibody Anti-Williams-Fitzgerald-Flaujeac Factor Cleaved Into - Kininogen-1 Heavy Chain - T-Kinin antibody Anti-Ile-Ser-Bradykinin - Bradykinin antibody Anti-Kallidin I - Lysyl-Bradykinin antibody Anti-Kallidin Ii - Kininogen-1 Light Chain - Low Molecular Weight Growth-Promoting Factor antibody Anti-KNG1 antibody Anti-BDK antibody Anti-KNG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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