产品详情
查看大图

  • 产品名称：Anti-Cleaved-KNG1-K380 antibody (300-380 aa) (STJ90095)

  • 产品型号：STJ90095
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Anti-Cleaved-KNG1-K380 antibody (300-380 aa) (STJ90095)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cleaved-Kininogen-1-K380 (300-380 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KNG1
Gene ID: 3827
Uniprot ID: KNG1_HUMAN
Immunogen Region: 300-380 aa
Specificity: Cleaved-Kininogen-1 HC (K380) Polyclonal Antibody detects endogenous levels of fragment of activated Kininogen-1 HC protein resulting from cleavage adjacent to K380.
Immunogen: Synthesized peptide derived from Cleaved-Kininogen-1 HC (K380) at the amino acid range 300-380
Post Translational Modifications Bradykinin: Bradykinin is inactivated by ACE, which removes the dipeptide Arg-Phe from its C-terminus. Bradykinin is released from kininogen by plasma kallikrein. Hydroxylation of Pro-383 occurs prior to the release of bradykinin. Phosphorylated by FAM20C in the extracellular medium. N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. (Microbial infection) Bradykinin is generated upon proteolytic cleavage by S.pyogenes SpeB to produce hypotension during septic shock.
Function Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII.HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. Bradykinin: The active peptide bradykinin is a potent vasodilatator that is released from HMW-kininogen shows a variety of physiological effects: (A) influence in smooth muscle contraction, (B) induction of hypotension, (C) natriuresis and diuresis, (D) decrease in blood glucose level, (E) it is a mediator of inflammation and causes (E1) increase in vascular permeability, (E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action).
Protein Name Kininogen-1
Alpha-2-Thiol Proteinase Inhibitor
Fitzgerald Factor
High Molecular Weight Kininogen
Hmwk
Williams-Fitzgerald-Flaujeac Factor Cleaved Into - Kininogen-1 Heavy Chain - T-Kinin
Ile-Ser-Bradykinin - Bradykinin
Kallidin I - Lysyl-Bradykinin
Kallidin Ii - Kininogen-1 Light Chain - Low Molecular Weight Growth-Promoting Factor
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-140837
Reactome: R-HSA-375276
Reactome: R-HSA-381426
Reactome: R-HSA-416476
Reactome: R-HSA-418594
Reactome: R-HSA-8957275
Cellular Localisation Secreted
Extracellular Space
Alternative Antibody Names Anti-Kininogen-1 antibody
Anti-Alpha-2-Thiol Proteinase Inhibitor antibody
Anti-Fitzgerald Factor antibody
Anti-High Molecular Weight Kininogen antibody
Anti-Hmwk antibody
Anti-Williams-Fitzgerald-Flaujeac Factor Cleaved Into - Kininogen-1 Heavy Chain - T-Kinin antibody
Anti-Ile-Ser-Bradykinin - Bradykinin antibody
Anti-Kallidin I - Lysyl-Bradykinin antibody
Anti-Kallidin Ii - Kininogen-1 Light Chain - Low Molecular Weight Growth-Promoting Factor antibody
Anti-KNG1 antibody
Anti-BDK antibody
Anti-KNG antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号