产品详情
查看大图

  • 产品名称：Anti-Cleaved-MMP14-Y112 antibody (93-142 aa) (STJ90060)

  • 产品型号：STJ90060
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Anti-Cleaved-MMP14-Y112 antibody (93-142 aa) (STJ90060)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cleaved-Matrix metalloproteinase-14-Y112 (93-142 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MMP14
Gene ID: 4323
Uniprot ID: MMP14_HUMAN
Immunogen Region: 93-142 aa
Specificity: Cleaved-MMP-14 (Y112) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-14 protein resulting from cleavage adjacent to Y112.
Immunogen: The antiserum was produced against synthesized peptide derived from the human MMP14 at the amino acid range 93-142
Post Translational Modifications The precursor is cleaved by a furin endopeptidase. Tyrosine phosphorylated by PKDCC/VLK.
Function Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis.
Protein Name Matrix Metalloproteinase-14
Mmp-14
Mmp-X1
Membrane-Type Matrix Metalloproteinase 1
Mt-Mmp 1
Mtmmp1
Membrane-Type-1 Matrix Metalloproteinase
Mt1-Mmp
Mt1mmp
Database Links Reactome: R-HSA-1442490
Reactome: R-HSA-1474228
Reactome: R-HSA-1592389
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Melanosome
Cytoplasm
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Forms A Complex With Bst2 And Localizes To The Cytoplasm
Alternative Antibody Names Anti-Matrix Metalloproteinase-14 antibody
Anti-Mmp-14 antibody
Anti-Mmp-X1 antibody
Anti-Membrane-Type Matrix Metalloproteinase 1 antibody
Anti-Mt-Mmp 1 antibody
Anti-Mtmmp1 antibody
Anti-Membrane-Type-1 Matrix Metalloproteinase antibody
Anti-Mt1-Mmp antibody
Anti-Mt1mmp antibody
Anti-MMP14 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号