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  • 产品名称：Human TNKS2 (Tankyrase 2) Sandwich ELISA Kit (STJE0012706)

  • 产品型号：STJE0012706
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human TNKS2 (Tankyrase 2) Sandwich ELISA Kit (STJE0012706)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.040ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This TNKS2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: TNKS2
Gene ID: 80351
Uniprot ID: TNKS2_HUMAN
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and brain.
Post Translational Modifications Ubiquitinated at 'Lys-48' and 'Lys-63' by RNF146 when auto-poly-ADP-ribosylated.this leads to degradation. ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination. The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer.
Function Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity.
Protein Name Poly Adp-Ribose Polymerase Tankyrase-2
Adp-Ribosyltransferase Diphtheria Toxin-Like 6
Artd6
Poly Adp-Ribose Polymerase 5b
Protein Poly-Adp-Ribosyltransferase Tankyrase-2
Tnks-2
Trf1-Interacting Ankyrin-Related Adp-Ribose Polymerase 2
Tankyrase Ii
Tankyrase-2
Tank2
Tankyrase-Like Protein
Tankyrase-Related Protein
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-4641257
Reactome: R-HSA-5545619
Reactome: R-HSA-5689880
Reactome: R-HSA-8948751
Cellular Localisation Cytoplasm
Golgi Apparatus Membrane
Peripheral Membrane Protein
Nucleus
Chromosome
Telomere
Associated With The Golgi And With Juxtanuclear Slc2a4/Glut4-Vesicles
Also Found Around The Pericentriolar Matrix Of Mitotic Centromeres
During Interphase
A Small Fraction Of Tnks2 Is Found In The Nucleus
Associated With Trf1
Alternative ELISA Names Poly Adp-Ribose Polymerase Tankyrase-2 ELISA kit
Adp-Ribosyltransferase Diphtheria Toxin-Like 6 ELISA kit
Artd6 ELISA kit
Poly Adp-Ribose Polymerase 5b ELISA kit
Protein Poly-Adp-Ribosyltransferase Tankyrase-2 ELISA kit
Tnks-2 ELISA kit
Trf1-Interacting Ankyrin-Related Adp-Ribose Polymerase 2 ELISA kit
Tankyrase Ii ELISA kit
Tankyrase-2 ELISA kit
Tank2 ELISA kit
Tankyrase-Like Protein ELISA kit
Tankyrase-Related Protein ELISA kit
TNKS2 ELISA kit
PARP5B ELISA kit
TANK2 ELISA kit
TNKL ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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