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  • 产品名称：Human TRPM1 (Transient Receptor Potential Cation Channel Subfamily M, Member 1) Sandwich ELISA Kit (STJE0012815)

  • 产品型号：STJE0012815
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human TRPM1 (Transient Receptor Potential Cation Channel Subfamily M, Member 1) Sandwich ELISA Kit (STJE0012815)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.051ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This TRPM1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: TRPM1
Gene ID: 4308
Uniprot ID: TRPM1_HUMAN
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Expressed in the retina where it localizes to the outer plexiform layer. Specifically, it is expressed in retinal bipolar cells (BPCs) of the ON subtype. Highly expressed in benign melanocytic nevi and diffusely expressed in various in situ melanomas, but not detected in melanoma metastases. Also expressed in melanocytes and pigmented metastatic melanoma cell lines. In melanocytes expression appears to be regulated at the level of transcription and mRNA processing.
Post Translational Modifications
Function Forms nonselective divalent cation-conducting channels which mediate the influx of Na(2+), Ca(2+), Mg(2+), Mn(2+), Ba(2+), and Ni(2+) into the cytoplasm, leading to membrane depolarization. Impermeable to zinc ions. In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions. Essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression. May act as a spontaneously active, calcium-permeable plasma membrane channel.
Protein Name Transient Receptor Potential Cation Channel Subfamily M Member 1
Long Transient Receptor Potential Channel 1
Ltrpc1
Melastatin-1
Database Links Reactome: R-HSA-3295583
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Cell Projection
Axon
Alternative ELISA Names Transient Receptor Potential Cation Channel Subfamily M Member 1 ELISA kit
Long Transient Receptor Potential Channel 1 ELISA kit
Ltrpc1 ELISA kit
Melastatin-1 ELISA kit
TRPM1 ELISA kit
LTRPC1 ELISA kit
MLSN ELISA kit
MLSN1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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