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  • 产品名称：Human XPO1 (Exportin 1) Sandwich ELISA Kit (STJE0013127)

  • 产品型号：STJE0013127
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human XPO1 (Exportin 1) Sandwich ELISA Kit (STJE0013127)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.123ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This XPO1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: XPO1
Gene ID: 7514
Uniprot ID: XPO1_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney.
Post Translational Modifications
Function Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.
Protein Name Exportin-1
Exp1
Chromosome Region Maintenance 1 Protein Homolog
Database Links Reactome: R-HSA-141444
Reactome: R-HSA-165054
Reactome: R-HSA-168333
Reactome: R-HSA-2173788
Reactome: R-HSA-2467813
Reactome: R-HSA-2500257
Reactome: R-HSA-3769402
Reactome: R-HSA-450520
Reactome: R-HSA-5663220
Reactome: R-HSA-5687128
Reactome: R-HSA-68877
Reactome: R-HSA-69273
Reactome: R-HSA-9634638
Reactome: R-HSA-9648025
Reactome: R-HSA-9707616
Reactome: R-HSA-9768919
Cellular Localisation Cytoplasm
Nucleus
Nucleoplasm
Cajal Body
Nucleolus
Located In The Nucleoplasm
Cajal Bodies And Nucleoli
Shuttles Between The Nucleus/Nucleolus And The Cytoplasm
Alternative ELISA Names Exportin-1 ELISA kit
Exp1 ELISA kit
Chromosome Region Maintenance 1 Protein Homolog ELISA kit
XPO1 ELISA kit
CRM1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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