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  • 产品名称：Mouse ABCG2 (ATP Binding Cassette Transporter G2) Sandwich ELISA Kit Ready-To-Use (STJE0013206)

  • 产品型号：STJE0013206
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse ABCG2 (ATP Binding Cassette Transporter G2) Sandwich ELISA Kit Ready-To-Use (STJE0013206)
详情介绍：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.055ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This ABCG2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Abcg2
Gene ID: 26357
Uniprot ID: ABCG2_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Highly expressed in kidney. Lower expression in liver, colon, heart, spleen, and placenta. Expressed in mammary gland. Expressed in intestinal villi and renal proximal tubules, hepatic bile canalicular membranes, and placental labyrinth cells (at protein level).
Post Translational Modifications N-glycosylated. Glycosylation-deficient ABCG2 is normally expressed and functional. Phosphorylated. Phosphorylation may regulate the localization to the plasma membrane, the homooligomerization and therefore, the activity of the transporter.
Function Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extrarenal urate excretion. In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate. Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates. Mediates the secretion of the riboflavin and biotin vitamins into milk. Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability. Plays an important role in the exclusion of xenobiotics from the brain. It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux. In placenta, it limits the penetration of drugs from the maternal plasma into the fetus. May play a role in early stem cell self-renewal by blocking differentiation (Probable).
Protein Name Broad Substrate Specificity Atp-Binding Cassette Transporter Abcg2
Atp-Binding Cassette Sub-Family G Member 2
Breast Cancer Resistance Protein 1 Homolog
Urate Exporter
Cd Antigen Cd338
Database Links Reactome: R-MMU-189451
Reactome: -MMU-189483
Reactome: -MMU-917937
Reactome: -MMU-9753281
Reactome: -MMU-9793528
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Apical Cell Membrane
Mitochondrion Membrane
Enriched In Membrane Lipid Rafts
Alternative ELISA Names Broad Substrate Specificity Atp-Binding Cassette Transporter Abcg2 ELISA kit
Atp-Binding Cassette Sub-Family G Member 2 ELISA kit
Breast Cancer Resistance Protein 1 Homolog ELISA kit
Urate Exporter ELISA kit
Cd Antigen Cd338 ELISA kit
Abcg2 ELISA kit
Abcp ELISA kit
Bcrp1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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