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  • 产品名称：Anti-CRTC3 antibody (1-260) (STJ118335)

  • 产品型号：STJ118335
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CRTC3 antibody (1-260) (STJ118335)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CRTC3 (1-260) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CRTC3
Gene ID: 64784
Uniprot ID: CRTC3_HUMAN
Immunogen Region: 1-260
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human CRTC3 (NP_073606.3).
Immunogen Sequence: MAASPGSGSANPRKFSEKIA LHTQRQAEETRAFEQLMTDL TLSRVQFQKLQQLRLTQYHG GSLPNVSQLRSSASEFQPSF HQADNVRGTRHHGLVERPSR NRFHPLHRRSGDKPGRQFDG SAFGANYSSQPLDESWPRQQ PPWKDEKHPGFRLTSALNRT NSDSALHTSALSTKPQDPYG GGGQSAWPAPYMGFCDGENN GHGEVASFPGPLKEENLLNV PKPLPKQLWETKEIQSLSG
Tissue Specificity Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.
Post Translational Modifications Phosphorylation/dephosphorylation states of Ser-273 are required for regulating transduction of CREB activity. CRTCs/TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. May be phosphorylated at Ser-391 by MAPK3/ERK1 and/or MAPK1/ERK2 or by some cyclin-dependent kinases such as CDK1,CDK2 or CDK5. Following adenylyl cyclase activation, dephosphorylated at Ser-162 and Ser-273 resulting in its dissociation from 14-3-3 proteins probably promoting CRTC3 translocation into the nucleus.
Function Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
Protein Name Creb-Regulated Transcription Coactivator 3
Transducer Of Regulated Camp Response Element-Binding Protein 3
Torc-3
Transducer Of Creb Protein 3
Database Links Reactome: R-HSA-2151201
Reactome: R-HSA-400253
Reactome: R-HSA-9707616
Cellular Localisation Nucleus
Cytoplasm
Appears To Be Mainly Nuclear
Translocates To The Nucleus Following Adenylyl Cyclase Or Map Kinase Activation
Alternative Antibody Names Anti-Creb-Regulated Transcription Coactivator 3 antibody
Anti-Transducer Of Regulated Camp Response Element-Binding Protein 3 antibody
Anti-Torc-3 antibody
Anti-Transducer Of Creb Protein 3 antibody
Anti-CRTC3 antibody
Anti-TORC3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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