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  • 产品名称：Mouse BMP-7 (Bone Morphogenetic Protein 7) CLIA Kit (STJC0001115)

  • 产品型号：STJC0001115
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse BMP-7 (Bone Morphogenetic Protein 7) CLIA Kit (STJC0001115)
详情介绍：
Applications: CLIA
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Sensitivity: 4.69pg/mL
Detection Limit: 7.81~500pg/mL
Short Description: This mouse BMP-7 kit is a highly sensitive in-vitro chemiluminescent immunoassay for the measurement of trace amounts of analytes.
Storage Instruction: If unopened the kit may be stored at 2-8°C for up to 1 month. If the kit will not be used within 1 month, store the components separately, according to the component table in the manual.
Assay Time: 3.5h
Detection: Chemiluminescence
Gene Symbol: Bmp7
Gene ID: 12162
Uniprot ID: BMP7_MOUSE
Specificity: This kit recognizes Mouse BMP-7 in samples. No significant cross-reactivity or interference between Mouse BMP-7 and analogues was observed.
Sample Type: Serum, plasma and other biological fluids
Function Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor. Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors. Promotes the expression of HAMP, this is repressed by its interaction with ERFE.
Protein Name Bone Morphogenetic Protein 7
Bmp-7
Osteogenic Protein 1
Op-1
Database Links Reactome: R-MMU-2129379
Cellular Localisation Secreted
Alternative CLIA Names Bone Morphogenetic Protein 7 CLIA kit
Bmp-7 CLIA kit
Osteogenic Protein 1 CLIA kit
Op-1 CLIA kit
Bmp7 CLIA kit
Bmp-7 CLIA kit
Op1 CLIA kit
Specificity This kit recognizes Mouse BMP-7 in samples. No significant cross-reactivity or interference between Mouse BMP-7 and analogues was observed.
Reproducibility Both intra-CV and inter-CV are

Information sourced from Uniprot.org


Item Specifications Storage
Micro CLIA Plate (Dismountable) 96T: 8 wells ×12 strips strips -20℃, 6 months
Reference Standard 96T: 2 vials 48T: 1 vial -20℃, 6 months
Concentrated Biotinylated Detection Ab (100×) 96T: 1 vial, 120 μL 60 μL -20℃, 6 months
Concentrated HRP Conjugate (100×) 96T: 1 vial, 120 μL 60 μL -20℃ (Protect from light), 6 months
Reference Standard & Sample Diluent 1 vial, 20 mL 2-8°C, 6 months
Biotinylated Detection Ab Diluent 1 vial, 14 mL 2-8°C, 6 months
HRP Conjugate Diluent 1 vial, 14 mL 2-8°C, 6 months
Concentrated Wash Buffer (25×) 1 vial, 30 mL 2-8°C, 6 months
Substrate Reagent A 1 vial, 5 mL 2-8℃ (Protect from light)
Substrate Reagent B 1 vial, 5 mL 2-8℃ (Protect from light)
Plate Sealer 5 pieces
Manual 1 copy
Certificate of Analysis 1 copy

Sample Type Range (%) Average Recovery (%)
Serum(n=8) 86-102 93
EDTA plasma(n=8) 84-99 91
Cell culture media(n=8) 92-104 99

Intra-assay Precision Intra-assay Precision Intra-assay Precision Inter-assay Precision Inter-assay Precision Inter-assay Precision
Sample 1.00 2.00 3.00 1.00 2.00 3.00
n 20.00 20.00 20.00 20.00 20.00 20.00
Mean (pg/mL) 23.42 68.75 194.30 25.66 70.65 182.73
Standard deviation 2.20 4.87 21.10 2.26 6.97 18.15
CV (%) 9.39 7.08 10.86 8.81 9.87 9.93
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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