产品详情
查看大图

  • 产品名称：Anti-CTTN antibody (301-400) (STJ28359)

  • 产品型号：STJ28359
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Anti-CTTN antibody (301-400) (STJ28359)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CTTN (301-400) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CTTN
Gene ID: 2017
Uniprot ID: SRC8_HUMAN
Immunogen Region: 301-400
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 301-400 of human Cortactin (NP_005222.2).
Immunogen Sequence: DYSKGFGGKYGVQKDRMDKN ASTFEDVTQVSSAYQKTVPV EAVTSKTSNIRANFENLAKE KEQEDRRKAEAERAQRMAKE RQEQEEARRKLEEQARAKTQ
Post Translational Modifications Phosphorylated by PKN2 at both serine and threonine residues in a GTP-bound Rac1-dependent manner in hyaluronan-induced astrocytes and hence down-regulated CTTN ability to associates with filamentous actin. Phosphorylated on tyrosine residues in response to CHRM1 activation. Phosphorylated by PTK2/FAK1 in response to cell adhesion. Phosphorylated by FER. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation. Phosphorylated in response to FGR activation. Phosphorylation by SRC promotes MYLK binding. Acetylated.
Function Contributes to the organization of the actin cytoskeleton and cell shape. Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density. Plays a role in focal adhesion assembly and turnover. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane. Plays a role in receptor-mediated endocytosis via clathrin-coated pits. Required for stabilization of KCNH1 channels at the cell membrane. Plays a role in the invasiveness of cancer cells, and the formation of metastases.
Protein Name Src Substrate Cortactin
Amplaxin
Oncogene Ems1
Database Links Reactome: R-HSA-5627123
Reactome: R-HSA-8856828
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Projection
Lamellipodium
Ruffle
Dendrite
Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Podosome
Cell Junction
Focal Adhesion
Membrane
Clathrin-Coated Pit
Dendritic Spine
Cell Cortex
Endoplasmic Reticulum
Colocalizes Transiently With Ptk2/Fak1 At Focal Adhesions
Associated With Membrane Ruffles And Lamellipodia
In The Presence Of Cttnbp2nl
Colocalizes With Stress Fibers
In The Presence Of Cttnbp2
Localizes At The Cell Cortex
In Response To Neuronal Activation By Glutamate
Redistributes From Dendritic Spines To The Dendritic Shaft
Colocalizes With Dnm2 At The Basis Of Filopodia In Hippocampus Neuron Growth Zones
Alternative Antibody Names Anti-Src Substrate Cortactin antibody
Anti-Amplaxin antibody
Anti-Oncogene Ems1 antibody
Anti-CTTN antibody
Anti-EMS1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号