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  • 产品名称：Anti-CYP17A1 antibody (209-508) (STJ115903)

  • 产品型号：STJ115903
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CYP17A1 antibody (209-508) (STJ115903)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CYP17A1 (209-508) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CYP17A1
Gene ID: 1586
Uniprot ID: CP17A_HUMAN
Immunogen Region: 209-508
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 209-508 of human CYP17A1 (NP_000093.1).
Immunogen Sequence: LSKDSLVDLVPWLKIFPNKT LEKLKSHVKIRNDLLNKILE NYKEKFRSDSITNMLDTLMQ AKMNSDNGNAGPDQDSELLS DNHILTTIGDIFGAGVETTT SVVKWTLAFLLHNPQVKKKL YEEIDQNVGFSRTPTISDRN RLLLLEATIREVLRLRPVAP MLIPHKANVDSSIGEFAVDK GTEVIINLWALHHNEKEWHQ PDQFMPERFLNPAGTQLISP SVSYLPFGAGPRSCIGEIL
Post Translational Modifications Phosphorylation is necessary for 17,20-lyase, but not for 17-alpha-hydroxylase activity.
Function A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol (Probable). Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase).
Protein Name Steroid 17-Alpha-Hydroxylase/17 -20 Lyase
17-Alpha-Hydroxyprogesterone Aldolase
Cypxvii
Cytochrome P450 17a1
Cytochrome P450-C17
Cytochrome P450c17
Steroid 17-Alpha-Monooxygenase
Database Links Reactome: R-HSA-193048
Reactome: R-HSA-194002
Reactome: R-HSA-5579028
Cellular Localisation Endoplasmic Reticulum Membrane
Microsome Membrane
Alternative Antibody Names Anti-Steroid 17-Alpha-Hydroxylase/17 -20 Lyase antibody
Anti-17-Alpha-Hydroxyprogesterone Aldolase antibody
Anti-Cypxvii antibody
Anti-Cytochrome P450 17a1 antibody
Anti-Cytochrome P450-C17 antibody
Anti-Cytochrome P450c17 antibody
Anti-Steroid 17-Alpha-Monooxygenase antibody
Anti-CYP17A1 antibody
Anti-CYP17 antibody
Anti-S17AH antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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