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  • 产品名称：Anti-CYP24A1 antibody (36-448) (STJ23319)

  • 产品型号：STJ23319
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CYP24A1 antibody (36-448) (STJ23319)
详情介绍：
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CYP24A1 (36-448) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IHC-P 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CYP24A1
Gene ID: 1591
Uniprot ID: CP24A_HUMAN
Immunogen Region: 36-448
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 36-448 of human CYP24A1 (NP_001122387.1).
Immunogen Sequence: PQPREVPVCPLTAGGETQNA AALPGPTSWPLLGSLLQILW KGGLKKQHDTLVEYHKKYGK IFRMKLGSFESVHLGSPCLL EALYRTESAYPQRLEIKPWK AYRDYRKEGYGLLILEGEDW QRVRSAFQKKLMKPGEVMKL DNKINEVLADFMGRIDELCD ERGHVEDLYSELNKWSFESI CLVLYEKRFGLLQKNAGDEA VNFIMAIKTMMSTFGRMMVT PVELHKSLNTKVWQDHTLA
Function A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24- and C23-oxidation pathways, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)). With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid. With initial hydroxylation at C-23 (via C23-oxidation pathway), catalyzes sequential oxidation of calcidiol leading to the formation of 25(OH)D3-26,23-lactone as end product. Preferentially hydroxylates at C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S-hydroxycholecalciferol and 20S,23-dihydroxycholecalciferol. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin.
Protein Name 1 -25-Dihydroxyvitamin D(3 24-Hydroxylase - Mitochondrial
24-Ohase
Vitamin D(3 24-Hydroxylase
Cytochrome P450 24a1
Cytochrome P450-Cc24
Database Links Reactome: R-HSA-196791
Reactome: R-HSA-211916
Reactome: R-HSA-5579010
Cellular Localisation Mitochondrion
Alternative Antibody Names Anti-1 -25-Dihydroxyvitamin D(3 24-Hydroxylase - Mitochondrial antibody
Anti-24-Ohase antibody
Anti-Vitamin D(3 24-Hydroxylase antibody
Anti-Cytochrome P450 24a1 antibody
Anti-Cytochrome P450-Cc24 antibody
Anti-CYP24A1 antibody
Anti-CYP24 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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