产品详情
查看大图

  • 产品名称：Anti-Catenin alpha1 antibody (Internal) (STJ70919)

  • 产品型号：STJ70919-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Anti-Catenin alpha1 antibody (Internal) (STJ70919)
详情介绍：
Host: Goat
Applications: Pep-ELISA/WB/IHC
Reactivity: Human/Mouse/Rat/Dog
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-Catenin alpha1 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-1-3µg/ml
IHC-3.75µg/ml
ELISA-antibody detection limit dilution 1:32000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: CTNNA1
Gene ID: 1495
Uniprot ID: CTNA1_HUMAN
Immunogen Region: Internal
Accession Number: NP_001894.2
Immunogen Sequence: KREKQDETQTKIK
Post Translational Modifications Sumoylated. Phosphorylation seems to contribute to the strength of cell-cell adhesion rather than to the basic capacity for cell-cell adhesion.
Function Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. May play a crucial role in cell differentiation.
Protein Name Catenin Alpha-1
Alpha E-Catenin
Cadherin-Associated Protein
Renal Carcinoma Antigen Ny-Ren-13
Database Links Reactome: R-HSA-418990
Reactome: R-HSA-5218920
Reactome: R-HSA-525793
Reactome: R-HSA-5626467
Reactome: R-HSA-9762292
Reactome: R-HSA-9764302
Reactome: R-HSA-9833576
Cellular Localisation Isoform 1: Cytoplasm
Cytoskeleton
Cell Junction
Adherens Junction
Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Found At Cell-Cell Boundaries And Probably At Cell-Matrix Boundaries
Isoform 3: Cell Membrane
Alternative Antibody Names Anti-Catenin Alpha-1 antibody
Anti-Alpha E-Catenin antibody
Anti-Cadherin-Associated Protein antibody
Anti-Renal Carcinoma Antigen Ny-Ren-13 antibody
Anti-CTNNA1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号