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  • 产品名称：Anti-CCDC47 antibody (224-483) (STJ118316)

  • 产品型号：STJ118316
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CCDC47 antibody (224-483) (STJ118316)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CCDC47 (224-483) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CCDC47
Gene ID: 57003
Uniprot ID: CCD47_HUMAN
Immunogen Region: 224-483
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 224-483 of human CCDC47 (NP_064583.2).
Immunogen Sequence: FLKRQDLLNVLARMMRPVSD QVQIKVTMNDEDMDTYVFAV GTRKALVRLQKEMQDLSEFC SDKPKSGAKYGLPDSLAILS EMGEVTDGMMDTKMVHFLTH YADKIESVHFSDQFSGPKIM QEEGQPLKLPDTKRTLLFTF NVPGSGNTYPKDMEALLPLM NMVIYSIDKAKKFRLNREGK QKADKNRARVEENFLKLTHV QRQEAAQSRREEKKRAEKER IMNEEDPEKQRRLEEAALR
Function Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein. Within the PAT subcomplex, CCDC47 occludes the lateral gate of the SEC61 complex. Involved in the regulation of calcium ion homeostasis in the ER. Required for proper protein degradation via the ERAD (ER-associated degradation) pathway. Has an essential role in the maintenance of ER organization during embryogenesis.
Protein Name Pat Complex Subunit Ccdc47
Calumin
Coiled-Coil Domain-Containing Protein 47
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type I Membrane Protein
Rough Endoplasmic Reticulum Membrane
Alternative Antibody Names Anti-Pat Complex Subunit Ccdc47 antibody
Anti-Calumin antibody
Anti-Coiled-Coil Domain-Containing Protein 47 antibody
Anti-CCDC47 antibody
Anti-GK001 antibody
Anti-MSTP041 antibody
Anti-PSEC0077 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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