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  • 产品名称：Anti-CLTC-H Chain antibody (50aa to N-Term) (STJ140022)

  • 产品型号：STJ140022
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CLTC-H Chain antibody (50aa to N-Term) (STJ140022)
详情介绍：
Host: Goat
Applications: WB/IF
Reactivity: Human/Rat/Mouse/Monkey/Canine
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-Clathrin-H Chain (50aa to N-Term) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS, 20% Glycerol and 0.05% Sodium Azide.
Purification: This antibody is epitope-affinity purified from goat antiserum.
Concentration: 2 mg/ml
Dilution Range: WB 1:250-1:1000
IF 1:25-1:250
Imbastari F PhD Thesis Humboldt-Universität zu Berlin Germany 2020
Caì Y Postnikova EN Bernbaum JG et al. J Virol. 2015 Jan 1:89 (1:844-56. PMID: 25355889
Storage Instruction: For continuous use, store at 2-8 C for one-two days. For extended storage, store in-20 C freezer. Working dilution samples should be discarded if not used within 12 hours.
Gene Symbol: CLTC
Gene ID: 1213
Uniprot ID: CLH1_HUMAN
Immunogen Region: 50aa to N-Term
Accession Number: ENSG00000141367
Specificity: Detects endogenous levels of total CLTC by Western blot in the whole cell lysates (MDCK, At-T20, COS-7).
Immunogen: Purified recombinant peptide derived from within residues 50 aa to N-terminus of human CLTC produced in E. coli.
Immunogen Sequence: M A Q I L P I R F Q E H L Q L Q N L G I N P A N I G F S T L T M E S D K F I C I R E K V G E Q A Q V V I I
Function Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Plays a role in early autophagosome formation.
Protein Name Clathrin Heavy Chain 1
Clathrin Heavy Chain On Chromosome 17
Clh-17
Database Links Reactome: R-HSA-168275
Reactome: R-HSA-177504
Reactome: R-HSA-190873
Reactome: R-HSA-196025
Reactome: R-HSA-2132295 Q00610-1
Reactome: R-HSA-3928665
Reactome: R-HSA-432720 Q00610-1
Reactome: R-HSA-432722 Q00610-1
Reactome: R-HSA-437239
Reactome: R-HSA-5099900
Reactome: R-HSA-5140745
Reactome: R-HSA-8856825
Reactome: R-HSA-8856828
Reactome: R-HSA-8866427
Reactome: R-HSA-8964038
Reactome: R-HSA-9013420
Reactome: R-HSA-9013424
Reactome: R-HSA-9700645
Reactome: R-HSA-9725370
Reactome: R-HSA-9725371
Cellular Localisation Cytoplasmic Vesicle Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Membrane
Coated Pit
Melanosome
Cytoplasm
Cytoskeleton
Spindle
Cytoplasmic Face Of Coated Pits And Vesicles
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
In Complex With Tacc3 And Ckap5 (Forming The Tacc3/Ch-Tog/Clathrin Complex) Localized To Inter-Microtubule Bridges In Mitotic Spindles
Alternative Antibody Names Anti-Clathrin Heavy Chain 1 antibody
Anti-Clathrin Heavy Chain On Chromosome 17 antibody
Anti-Clh-17 antibody
Anti-CLTC antibody
Anti-CLH17 antibody
Anti-CLTCL2 antibody
Anti-KIAA0034 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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