产品详情
简单介绍：
Anti-CYBB antibody (111-160 aa) (STJ96748)
详情介绍：
| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Cytochrome b-245 heavy chain subunit beta (111-160 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC-P 1:100-1:300 ELISA 1:20000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CYBB |
| Gene ID: | 1536 |
| Uniprot ID: | CY24B_HUMAN |
| Immunogen Region: | 111-160 aa |
| Specificity: | gp91-phox Polyclonal Antibody detects endogenous levels of gp91-phox protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the Internal region of human CYBB at the amino acid range 111-160 |
| Post Translational Modifications | Glycosylated. Phosphorylated on Ser and Thr residues. Undergoes 'Lys-48'-linked polyubiquitination, likely by RNF145, triggering endoplasmic reticulum-associated degradation. |
| Function | Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. |
| Protein Name | Cytochrome B-245 Heavy Chain Cgd91-Phox Cytochrome B(558 Subunit Beta Cytochrome B558 Subunit Beta Heme-Binding Membrane Glycoprotein Gp91phox Nadph Oxidase 2 Neutrophil Cytochrome B 91 Kda Polypeptide Superoxide-Generating Nadph Oxidase Heavy Chain Subunit Gp91-1 Gp91-Phox P22 Phagocyte B-Cytochrome |
| Database Links | Reactome: R-HSA-1222556 Reactome: R-HSA-1236973 Reactome: R-HSA-3299685 Reactome: R-HSA-4420097 Reactome: R-HSA-5668599 Reactome: R-HSA-6798695 Reactome: R-HSA-9013149 Reactome: R-HSA-9013404 Reactome: R-HSA-9013423 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein As Unassembled Monomer May Localize To The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Cytochrome B-245 Heavy Chain antibody Anti-Cgd91-Phox antibody Anti-Cytochrome B(558 Subunit Beta antibody Anti-Cytochrome B558 Subunit Beta antibody Anti-Heme-Binding Membrane Glycoprotein Gp91phox antibody Anti-Nadph Oxidase 2 antibody Anti-Neutrophil Cytochrome B 91 Kda Polypeptide antibody Anti-Superoxide-Generating Nadph Oxidase Heavy Chain Subunit antibody Anti-Gp91-1 antibody Anti-Gp91-Phox antibody Anti-P22 Phagocyte B-Cytochrome antibody Anti-CYBB antibody Anti-NOX2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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