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  • 产品名称：Anti-CYP2C9 antibody (211-490) (STJ27975)

  • 产品型号：STJ27975
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CYP2C9 antibody (211-490) (STJ27975)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CYP2C9 (211-490) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CYP2C9
Gene ID: 1559
Uniprot ID: CP2C9_HUMAN
Immunogen Region: 211-490
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 211-490 of human CYP2C9 (NP_000762.2).
Immunogen Sequence: PWIQICNNFSPIIDYFPGTH NKLLKNVAFMKSYILEKVKE HQESMDMNNPQDFIDCFLMK MEKEKHNQPSEFTIESLENT AVDLFGAGTETTSTTLRYAL LLLLKHPEVTAKVQEEIERV IGRNRSPCMQDRSHMPYTDA VVHEVQRYIDLLPTSLPHAV TCDIKFRNYLIPKGTTILIS LTSVLHDNKEFPNPEMFDPH HFLDEGGNFKKSKYFMPFSA GKRICVGEALAGMELFLFL
Function A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2. Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol. Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Protein Name Cytochrome P450 2c9
(R-Limonene 6-Monooxygenase
(S-Limonene 6-Monooxygenase
(S-Limonene 7-Monooxygenase
Cypiic9
Cholesterol 25-Hydroxylase
Cytochrome P-450mp
Cytochrome P450 Mp-4
Cytochrome P450 Mp-8
Cytochrome P450 Pb-1
S-Mephenytoin 4-Hydroxylase
Database Links Reactome: R-HSA-211981
Reactome: R-HSA-211999
Reactome: R-HSA-2142670
Reactome: R-HSA-2142816
Reactome: R-HSA-9027307
Reactome: R-HSA-9749641
Cellular Localisation Endoplasmic Reticulum Membrane
Peripheral Membrane Protein
Microsome Membrane
Alternative Antibody Names Anti-Cytochrome P450 2c9 antibody
Anti-(R-Limonene 6-Monooxygenase antibody
Anti-(S-Limonene 6-Monooxygenase antibody
Anti-(S-Limonene 7-Monooxygenase antibody
Anti-Cypiic9 antibody
Anti-Cholesterol 25-Hydroxylase antibody
Anti-Cytochrome P-450mp antibody
Anti-Cytochrome P450 Mp-4 antibody
Anti-Cytochrome P450 Mp-8 antibody
Anti-Cytochrome P450 Pb-1 antibody
Anti-S-Mephenytoin 4-Hydroxylase antibody
Anti-CYP2C9 antibody
Anti-CYP2C10 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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